In the present review, we discuss the results of the research we have done over the last decade on multi-porphyrinic architectures bearing a nucleotidic backbone, compare all the data, offer a novel overview, and emphasize common capabilities of nucleosides appearing in various systems, providing a new insight on the pre-organizing capabilities of nucleosidic backbones. The efficiency of nucleosides as pre-organizing agents was investigated through the synthesis and study of various bis-porphyrins bearing nucleosidic linkers, as well as through the investigation of the conformation of linear and arborescent multi-porphyrins constructed on a nucleosidic backbone. The capacity of these molecules to complex guests with a high association constant was used as a tool to evaluate their degree of pre-organization, as well as the investigation of the electronic coupling existing between their chromophores and their photo-chemical capacities. Such an overview of one decade of scientific investigations documents the fact that rigid linkers between chromophores are not necessary for their spatial pre-organization, opening new routes to the faster synthesis of flexible highly pre-organized molecular architectures avoiding the long and tedious synthesis of rigid tweezers, especially for the preparation of rigid linkers which may bring solubility and stability problems.

中文翻译：

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核苷作为组织剂

在本综述中，我们讨论了我们在过去十年中对带有核苷酸骨架的多卟啉结构所做的研究结果，比较了所有数据，提供了一个新颖的概述，并强调了出现在各种系统中的核苷的共同能力，为核苷骨架的预组织能力提供了新的见解。通过合成和研究各种带有核苷接头的双卟啉，以及通过研究构建在核苷骨架上的线性和树枝状多卟啉的构象，研究了核苷作为预组织剂的效率。这些分子对具有高缔合常数的复合客体的能力被用作评估其预组织程度的工具，以及研究它们的发色团和它们的光化学能力之间存在的电子耦合。这种对十年科学研究的概述记录了这样一个事实，即发色团之间的刚性连接体对于它们的空间预组织不是必需的，为更快合成灵活的高度预组织的分子结构开辟了新途径，避免了漫长而繁琐的刚性合成镊子，特别是用于制备可能带来溶解性和稳定性问题的刚性接头。