An amphiphilic zinc porphyrin complex with a typical donor–acceptor (D–A) structure was synthesized, where the triphenylamine acted as a donor unit while the porphyrin was used as an electronic acceptor. Due to the presence of triethylene glycol moieties on the parent structure, Zn-TPAP could spontaneously assemble to the related nanoparticles (Zn-TPAP NPs) with improved hydrophilicity. The as-prepared Zn-TPAP NPs presented relatively uniform spherical particles with the average particle sizes around 160 nm, which was suitable for tumor accumulation benefiting from the EPR effect. Due to the aggregation of the porphyrin molecules in the assembled nanostructures, Zn-TPAP NPs displayed broadened and red-shifted absorption and quenched fluorescence relative to that of Zn-TPAP. In addition to ROS generation, Zn-TPAP NPs exhibited moderate photothermal effects and the photothermal conversion efficiency was measured as 29%. Zn-TPAP NPs showed good biocompatibility and could generate ROS in the A549 cells. Under light irradiation, Zn-TPAP NPs can efficiently kill cancer cells. Thus, Zn-TPAP NPs could be used as potential nanoagents for cancer treatment through the photothermal/photodynamic synergistic modes.

中文翻译：

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具有光动力/光热活性的三苯胺取代的锌卟啉纳米颗粒用于癌症体外光疗

合成了具有典型供体-受体（D-A）结构的两亲锌卟啉络合物，其中三苯胺作为供体单元，而卟啉作为电子受体。由于母体结构上存在三甘醇部分，Zn-TPAP 可以自发组装成相关的纳米颗粒（Zn-TPAP NPs），并具有改善的亲水性。所制备的 Zn-TPAP NPs 呈现出相对均匀的球形颗粒，平均粒径约为 160 nm，受益于 EPR 效应，适合肿瘤聚集。由于卟啉分子在组装的纳米结构中的聚集，相对于 Zn-TPAP，Zn-TPAP NPs 显示出更宽的红移吸收和猝灭的荧光。除了生成 ROS，Zn-TPAP NPs表现出中等的光热效应，光热转换效率为29%。Zn-TPAP NPs 表现出良好的生物相容性，可以在 A549 细胞中产生 ROS。在光照下，Zn-TPAP NPs 可以有效杀死癌细胞。因此，Zn-TPAP NPs 可以通过光热/光动力协同模式用作癌症治疗的潜在纳米剂。