A novel porphyrin-dextran coated Fe3O4 nanoparticle (5) was designed and synthesized. The structure of 5 was confirmed by IR, UV-vis and inductively coupled plasma atomic emission spectrometry, and dynamic laser scattering (DLS); magnetic property was measured by a vibrating sample magnetometer (VSM). The interaction between compound 5 and human serum albumin (HSA) was investigated through UV-vis absorbance spectra and fluorospectrophotometer, compared with the 5-(4-aminophenyl)-10,15,20-tris-(4-sulfonatophenyl)porphyrin, trisodium salt (3). The results showed compound 5 containing porphyrin moiety and 3 could interact with HSA. The quenching constant (Ksv) was 4.739 × 105 M-1 for 3, and 2.846 × 105 M-1 for 5; the apparent affinity binding constant (KA) was 8.562 × 103 M-1 for 3, and 4.978 × 104 M-1 for 5.

中文翻译：

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新型卟啉-葡聚糖纳米粒与人血清白蛋白的相互作用

一种新型卟啉-葡聚糖包被的铁3○4纳米粒子（5）的设计和合成。5的结构通过IR、UV-vis和电感耦合等离子体原子发射光谱以及动态激光散射（DLS）进行了确认；磁性通过振动样品磁力计（VSM）测量。通过紫外可见吸收光谱和荧光分光光度计研究化合物5与人血清白蛋白（HSA）的相互作用，并与5-（4-氨基苯基）-10,15,20-三-（4-磺基苯基）卟啉三钠进行了比较盐（3）。结果表明含有卟啉部分的化合物5和3可以与HSA相互作用。淬火常数（Ksv) 为 4.739 × 105米-1对于 3 和 2.846 × 105米-15个；表观亲和力结合常数（K一种) 为 8.562 × 103米-1对于 3 和 4.978 × 104米-1为 5。