Hippo signaling pathway is a highly conserved and crucial signaling pathway that controls the size of tissues and organs by regulating the proliferation, differentiation, and apoptosis of cells. The nervous system is a complicated system that participates in information collection, integration, and procession. The balance of various aspects of the nervous system is vital for the normal regulation of physiological conditions of the body, like the population and distribution of nerve cells, nerve connections, and so on. Defects in these aspects may lead to cognitive, behavioral, and neurological dysfunction, resulting in various nervous system diseases. Recently, accumulating evidence proposes that Hippo pathway maintains numerous biological functions in the nervous system development, including modulating the proliferation and differentiation of nerve cells and promoting the development of synapse, corpus callosum, and cortex. In this review, we will summarize recent findings of Hippo pathway in the nervous system to improve our understanding on its function and to provide potential therapeutic strategies of nervous system diseases in the future.
Dev Neurosci

中文翻译：

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河马信号通路在神经系统发育中的作用

Hippo信号通路是一种高度保守且至关重要的信号通路，通过调节细胞的增殖、分化和凋亡来控制组织器官的大小。神经系统是一个参与信息收集、整合和处理的复杂系统。神经系统各方面的平衡对于身体生理状况的正常调节至关重要，如神经细胞的数量和分布、神经连接等。这些方面的缺陷可能导致认知、行为和神经功能障碍，从而导致各种神经系统疾病。最近，越来越多的证据表明，Hippo 通路在神经系统发育中维持着许多生物学功能，包括调节神经细胞的增殖和分化，促进突触、胼胝体和皮层的发育。在这篇综述中，我们将总结 Hippo 通路在神经系统中的最新发现，以提高我们对其功能的理解，并为未来的神经系统疾病提供潜在的治疗策略。
开发神经科学