Dingchuan decoction (DCD) is a traditional Chinese prescription for asthma that remains popular today. To systematically evaluate the effect of DCD on lung function, clinical effectiveness rate, and safety in children with asthma, significant databases were searched for randomized controlled trials from their inception to September 9, 2019. Randomized controlled trials assessing the effect of DCD on lung function and clinical effectiveness rate in children with asthma were included in this meta-analysis. The methodological quality of the included trials was assessed using the Cochrane risk of bias tool. RevMan 5.3 was used for data analysis. Fourteen studies with 1,384 children were reviewed. FEV₁ improvement rate (mean difference [MD] 12.50, 95% confidence interval [CI] 8.72–16.29), PEF improvement rate (MD 14.28, 95% CI 11.08–17.49), and clinical effectiveness rate (relative risk 1.19, 95% CI 1.14–1.25) significantly increased in the DCD group when compared to simple conventional medication. Four trials suggest that DCD is safe for children. In conclusion, the use of DCD combined with conventional medication improves lung function and clinical effectiveness rate better than simple conventional medication. However, the selected trials lack blinding and large-scale studies. Therefore, to better manage DCD in clinical practice, more randomized controlled trials and large-scale studies are required for further evaluation.
Complement Med Res

中文翻译：

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定喘汤对哮喘患儿肺功能及临床有效率的影响：系统评价及Meta分析

定喘汤 (DCD) 是一种治疗哮喘的传统中药方剂，至今仍广受欢迎。为系统评价DCD对哮喘患儿肺功能、临床有效率和安全性的影响，检索了重要数据库中从开始到2019年9月9日的随机对照试验。 评估DCD对肺功能影响的随机对照试验本荟萃分析包括哮喘患儿的临床有效率和临床有效率。使用 Cochrane 偏倚风险工具评估纳入试验的方法学质量。RevMan 5.3 用于数据分析。审查了 14 项涉及 1,384 名儿童的研究。肺活量₁改善率（平均差 [MD] 12.50，95% 置信区间 [CI] 8.72–16.29）、PEF 改善率（MD 14.28，95% CI 11.08–17.49）和临床有效率（相对风险 1.19，95% CI 1.14） –1.25) 与简单的常规药物治疗相比，DCD 组显着增加。四项试验表明 DCD 对儿童是安全的。综上所述，DCD联合常规药物使用比单纯常规药物更好地改善肺功能和临床有效率。然而，选定的试验缺乏盲法和大规模研究。因此，为了在临床实践中更好地管理 DCD，需要更多的随机对照试验和大规模研究进行进一步评估。
补充医学资源