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Non-enzymatic and rapid detection of glucose on PVA-CuO thin film using ARDUINO UNO based capacitance measurement unit
Biomedical Microdevices ( IF 3.0 ) Pub Date : 2021-07-14 , DOI: 10.1007/s10544-021-00568-x
Tarun Kumar Dhiman 1 , Mrinal Poddar 1 , G B V S Lakshmi 1 , Rahul Kumar 1, 2 , Pratima R Solanki 1
Affiliation  

Glucose measurement is one of the essential health monitoring practices for maintaining blood sugar levels. Here, we have fabricated a highly specific capacitive nano-sensor for non-enzymatic glucose detection. Capacitance measurements were carried out on polyvinyl alcohol capped copper oxide (PVA-CuO) thin films on indium tin oxide (ITO) coated glass using ARDUINO UNO. The capacitance study shows a decrease in capacitance with an increase in glucose concentrations. The applicability in real samples was performed by studying the glucose in the presence of fetal bovine serum. Most commonly found interfering agents were used for interference studies, which confirmed the capacitive nano-sensor specificity. The system was further checked for repeatability up to six readings and reproducibility up to 5 chips. The shelf-life study showed stability for four weeks of a chip. These studies indicate that this capacitance-based measurement unit can be used for reliable, rapid, and non-enzymatic detection of glucose in real sample.



中文翻译:

使用基于 ARDUINO UNO 的电容测量单元对 PVA-CuO 薄膜上的葡萄糖进行非酶促快速检测

葡萄糖测量是维持血糖水平的基本健康监测方法之一。在这里,我们制造了一种用于非酶葡萄糖检测的高特异性电容纳米传感器。使用 ARDUINO UNO 在氧化铟锡 (ITO) 涂层玻璃上的聚乙烯醇封端氧化铜 (PVA-CuO) 薄膜上进行电容测量。电容研究显示电容随着葡萄糖浓度的增加而降低。在实际样品中的适用性是通过在胎牛血清存在下研究葡萄糖来进行的。最常见的干扰剂用于干扰研究,这证实了电容纳米传感器的特异性。系统进一步检查了多达 6 个读数的重复性和多达 5 个芯片的再现性。保质期研究显示芯片的稳定性为 4 周。这些研究表明,这种基于电容的测量单元可用于可靠、快速和非酶法检测实际样品中的葡萄糖。

更新日期:2021-07-14
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