Introduction

Inherited phagocyte defects are one of the subgroups of primary immunodeficiency diseases (PIDs) with various clinical manifestations. As oral manifestations are common at the early ages, oral practitioners can have a special role in the early diagnosis.

Materials and methods

A comprehensive search was conducted in this systematic review study and data of included studies were categorized into four subgroups of phagocyte defects, including congenital neutropenia, defects of motility, defects of respiratory burst, and other non-lymphoid defects.

Results

Among all phagocyte defects, 12 disorders had reported data for oral manifestations in published articles. A total of 987 cases were included in this study. Periodontitis is one of the most common oral manifestations.

Conclusion

There is a need to organize better collaboration between medical doctors and dentists to diagnose and treat patients with phagocyte defects. Regular dental visits and professional oral health care are recommended from the time of the first primary teeth eruption in newborns.

中文翻译：

---

“吞噬细胞数量或功能遗传缺陷患者的口腔表现”系统评价

介绍

遗传性吞噬细胞缺陷是原发性免疫缺陷病 (PID) 的亚组之一，具有多种临床表现。由于口腔表现在早期很常见，因此口腔从业人员在早期诊断中可以发挥特殊作用。

材料和方法

本系统评价研究进行了全面检索，将纳入研究的数据分为吞噬细胞缺陷的四个亚组，包括先天性中性粒细胞减少症、运动缺陷、呼吸爆发缺陷和其他非淋巴缺陷。

结果

在所有吞噬细胞缺陷中，12 种疾病在已发表的文章中报告了口腔表现数据。本研究共纳入 987 例病例。牙周炎是最常见的口腔表现之一。

结论

需要组织医生和牙医之间更好的合作来诊断和治疗吞噬细胞缺陷的患者。建议从新生儿第一颗乳牙萌出时开始定期看牙医和进行专业的口腔保健。