B-cells contribute to MS pathogenesis. The association of circulating B-cell phenotypes with combined unique active lesions (CUA) on MRI at 48 weeks follow-up was investigated in 50 interferon beta-treated MS patients. Transitional B-cell proportions were lower in participants with CUA at week 0 and 48 [p = 0.004, p = 0.002]. A decrease in circulating anti-EBNA-1 IgG levels between week 0 and 48 associated with absence of CUA [p = 0.047], but not with B-cell profiles. In a multi-factor model for CUA-risk, transitional B-cell proportions contributed independent from NK/T-cell ratio, change in anti-EBNA-1 IgG, and vitamin D supplements. Transitional B-cells may predict treatment response in MS.

B 细胞有助于 MS 的发病机制。在 50 名干扰素 β 治疗的 MS 患者中研究了循环 B 细胞表型与 MRI 在 48 周随访时联合独特活动性病变 (CUA) 的关联。在第 0 周和第 48 周，患有 CUA 的参与者的过渡 B 细胞比例较低 [ p  = 0.004，p  = 0.002]。在第 0 周和第 48 周之间循环抗 EBNA-1 IgG 水平的降低与 CUA 缺失有关 [ p  = 0.047]，但与 B 细胞谱无关。在 CUA 风险的多因素模型中，过渡性 B 细胞比例的贡献独立于 NK/T 细胞比例、抗 EBNA-1 IgG 的变化和维生素 D 补充剂。过渡 B 细胞可以预测 MS 的治疗反应。