Systemic lupus erythematosus (SLE) is a recognized chronic condition associated with immune system disorders that affect women nine times more commonly than men. SLE is characterized by over-secretion and release of autoantibodies in response to different cellular compartments and self-tolerance breaks to its own antigens. The detailed immunological dysregulation as an associated event that elicits the onset of clinical manifestations of SLE has not been clarified yet. Though, research using several animal models in the last two decades has indicated the role of the immune system in the pathogenesis of this disease. Myeloid-derived suppressor cells (MDSCs) as heterogeneous myeloid cells, are responsible for severe pathological conditions, including infection, autoimmunity, and cancer, by exerting considerable immunosuppressive effects on T-cells responses. It has been reported that these cells are involved in the regulation process of the immune response in several autoimmune diseases, particularly SLE. The function of MDSC is deleterious in infection and cancer diseases, though their role is more complicated in autoimmune diseases. In this review, we summarized the role and function of MDSCs in the pathogenesis and progression of SLE and its possible therapeutic approach.

系统性红斑狼疮 (SLE) 是一种公认​​的与免疫系统疾病相关的慢性疾病，对女性的影响是男性的九倍。SLE 的特征是自身抗体的过度分泌和释放，以响应不同的细胞区室和对其自身抗原的自我耐受性中断。详细的免疫失调作为引起 SLE 临床表现发作的相关事件尚未阐明。然而，在过去的二十年中使用几种动物模型的研究表明免疫系统在这种疾病的发病机制中的作用。髓源性抑制细胞 (MDSCs) 作为异质骨髓细胞，是导致严重病理状况的原因，包括感染、自身免疫和癌症，通过对 T 细胞反应产生相当大的免疫抑制作用。据报道，这些细胞参与了几种自身免疫性疾病，特别是 SLE 中免疫反应的调节过程。MDSC 的功能在感染和癌症疾病中是有害的，尽管它们在自身免疫性疾病中的作用更为复杂。在这篇综述中，我们总结了 MDSCs 在 SLE 发病机制和进展中的作用和功能及其可能的治疗方法。