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Cure and prevention of cardiovascular diseases: herbs for heart
Clinical Phytoscience Pub Date : 2021-07-14 , DOI: 10.1186/s40816-021-00294-0
Suman Ray 1 , Mahesh Kumar Saini 1
Affiliation  

Herbs contribute to more than 60-70% in development of modern medicines in the world market either directly or indirectly. The herbal treatments for congestive heart failure, systolic hypertension, angina, atherosclerosis, cerebral insufficiency and venous insufficiency etc. has been known since ancient times. Unlike allopathic medicines, Ayurveda medicines are considered safe, however, the adverse reactions of herbal drugs is also reported. In this paper, we have compiled 128 herbs and their parts that have medicinal value to prevent, alleviate or cure heart disease related disorders. Jaccard Neighbour-joining cluster analysis using Free Tree software was used to assess the relative importance of plants in context with its healing potential for heart related disease. Based on the medicinal value in context with the heart, five major clusters of the selected 128 herbs were made. Correlation of the distance between herbs revealed that most of these herbs were found to have more than one medicinal property. The distance in dendogram depicted closeness of properties curing heart disease; as less the distance between two medicinal plants or two groups they will more close to cure particular heart disease. During drug development, a medicinal plant can be replaced by another plant of same group or by another plant of its neighbour group but from same pedigree. Thus, in case of non-availability of herbs or if it belongs to the category of rare, threatened, and endangered species, such method may add to new ways of drug development.

中文翻译:

心血管疾病的治疗和预防:心脏草药

草药直接或间接地为世界市场上现代药物的开发贡献了 60-70% 以上。治疗充血性心力衰竭、收缩期高血压、心绞痛、动脉粥样硬化、脑供血不足和静脉供血不足等的草药疗法自古为人所知。与对抗疗法药物不同,阿育吠陀药物被认为是安全的,然而,也有报道草药的不良反应。在本文中,我们整理了128种具有预防、缓解或治疗心脏病相关疾病的药用价值的草药及其部位。使用 Free Tree 软件的 Jaccard Neighbour-joining 聚类分析用于评估植物在其治疗心脏病相关疾病的潜力方面的相对重要性。基于与心脏有关的药用价值,对所选的 128 种草药制成了五个主要集群。草药之间距离的相关性表明,这些草药中的大多数被发现具有不止一种药用特性。树状图中的距离描述了治疗心脏病的特性的接近程度;两种药用植物或两组之间的距离越小,它们就越接近治愈特定的心脏病。在药物开发过程中,一种药用植物可以被同一组的另一种植物所替代,或者被其相邻组的另一种植物所替代,但来自同一谱系。因此,在无法获得草药或属于稀有、受威胁和濒危物种的情况下,这种方法可能会增加药物开发的新方法。草药之间距离的相关性表明,这些草药中的大多数被发现具有不止一种药用特性。树状图中的距离描述了治疗心脏病的特性的接近程度;两种药用植物或两组之间的距离越小,它们就越接近治愈特定的心脏病。在药物开发过程中,一种药用植物可以被同一组的另一种植物所替代,或者被其相邻组的另一种植物所替代,但属于同一谱系。因此,在无法获得草药或属于稀有、受威胁和濒危物种的情况下,这种方法可能会增加药物开发的新方法。草药之间距离的相关性表明,这些草药中的大多数被发现具有不止一种药用特性。树状图中的距离描述了治疗心脏病的特性的接近程度;两种药用植物或两组之间的距离越小,它们就越接近治愈特定的心脏病。在药物开发过程中,一种药用植物可以被同一组的另一种植物所替代,或者被其相邻组的另一种植物所替代,但来自同一谱系。因此,在无法获得草药或属于稀有、受威胁和濒危物种的情况下,这种方法可能会增加药物开发的新方法。两种药用植物或两组之间的距离越小,它们就越接近治愈特定的心脏病。在药物开发过程中,一种药用植物可以被同一组的另一种植物所替代,或者被其相邻组的另一种植物所替代,但来自同一谱系。因此,在无法获得草药或属于稀有、受威胁和濒危物种的情况下,这种方法可能会增加药物开发的新方法。两种药用植物或两组之间的距离越小,它们就越接近治愈特定的心脏病。在药物开发过程中,一种药用植物可以被同一组的另一种植物所替代,或者被其相邻组的另一种植物所替代,但属于同一谱系。因此,在无法获得草药或属于稀有、受威胁和濒危物种的情况下,这种方法可能会增加药物开发的新方法。
更新日期:2021-07-14
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