Epileptic spasms are a hallmark of a severe epileptic state. A previous study showed neocortical up and down states defined by unit activity play a role in the generation of spasms. However, recording unit activity is challenging in clinical settings, and more accessible neurophysiological signals are needed for the analysis of these brain states.

中文翻译：

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大脑状态依赖性高频活动作为癫痫痉挛动物模型中异常新皮质网络的生物标志物

癫痫痉挛是严重癫痫状态的标志。之前的一项研究表明，由单位活动定义的新皮质上下状态在痉挛的产生中发挥着作用。然而，在临床环境中记录单位活动具有挑战性，并且需要更容易获得的神经生理学信号来分析这些大脑状态。