The [¹⁸F]-JNJ-64326067-AAA ([¹⁸F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer’s disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs, 5 ADs, and 3 PSPs) received a [¹¹C]-PIB amyloid PET scan, and a tau [¹⁸F]-JNJ-067 PET scan 0-90 minutes post-injection. Only MCIs and ADs were amyloid positive. The simplified reference tissue model, Logan graphical analysis distribution volume ratio, and SUVR were evaluated for quantification. The [¹⁸F]-JNJ-067 tau signal relative to the reference region continued to increase to 90 min, indicating the tracer had not reached steady state. There was no significant difference in any bilateral ROIs for MCIs or PSPs relative to HCs; AD participants showed elevated tracer relative to controls in most cortical ROIs (P < 0.05). Only AD participants showed elevated retention in the entorhinal cortex. There was off-target signal in the putamen, pallidum, thalamus, midbrain, superior cerebellar gray, and white matter. [¹⁸F]-JNJ-067 significantly correlated (p < 0.05) with Mini-Mental State Exam in entorhinal cortex and temporal meta regions. There is clear binding of [¹⁸F]-JNJ-067 in AD participants. Lack of binding in HCs, MCIs and PSPs suggests [¹⁸F]-JNJ-067 may not bind to low levels of AD-related tau or 4 R tau.

[ ¹⁸ F]-JNJ-64326067-AAA ([ ¹⁸ F]-JNJ-067) tau 示踪剂在健康老年对照 (HC)、轻度认知障碍 (MCI)、阿尔茨海默病 (AD) 和进行性核上性麻痹中进行了评估(PSP) 参与者。17 名受试者（4 名 HC、5 名 MCI、5 名 AD 和 3 名 PSP）在注射后 0-90 分钟接受了 [ ¹¹ C]-PIB 淀粉样蛋白 PET 扫描和 tau [ ^{18 F]-JNJ-067 PET 扫描。}只有 MCI 和 AD 呈淀粉样蛋白阳性。对简化的参考组织模型、Logan 图形分析分布体积比和 SUVR 进行了量化评估。[ ¹⁸F]-JNJ-067 tau 信号相对于参考区域持续增加至 90 min，表明示踪剂尚未达到稳定状态。相对于 HC，MCI 或 PSP 的任何双边 ROI 没有显着差异；AD 参与者在大多数皮质 ROI 中显示出相对于对照组升高的示踪剂 (P < 0.05)。只有 AD 参与者的内嗅皮层保留率升高。壳核、苍白球、丘脑、中脑、小脑上灰质和白质均有脱靶信号。[ ¹⁸ F]-JNJ-067 与内嗅皮层和颞元区域的简易精神状态检查显着相关 (p < 0.05)。^{[ 18} F]-JNJ-067 在 AD 参与者中有明确的结合。HC、MCIs 和 PSP 缺乏结合表明 [ ¹⁸F]-JNJ-067 可能不与低水平的 AD 相关 tau 或 4 R tau 结合。