A new benzophenone derivative, hyperinokone (1), has been isolated from the aerial part of Hypericum nokoense, together with six known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (4), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (5), and eleocharin A (6) exhibited cytotoxicities, with IC₅₀ values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds 4 and 6 exhibited cytotoxicities, with IC₅₀ values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition, 3, 4, and 6 showed potent inhibition with IC₅₀ values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation.

已从金丝桃的地上部分分离出一种新的二苯甲酮衍生物金丝桃酮 ( 1 ) ，以及六种已知化合物。通过光谱和质谱分析确定了新化合物1的结构。在分离株中，异茉莉花红素 ( 4 ) 、5,4'-二羟基-3'-甲氧基-(6:7)-2,2-二甲基吡喃黄酮 ( 5 ) 和马齿苋素 A ( 6 ) 表现出细胞毒性，IC ₅₀值为针对 DLD-1 细胞系分别为 4.16、6.28 和 5.98 μM。化合物4和6表现出细胞毒性，IC ₅₀针对 IMR-32 细胞系的值分别为 5.24 和 4.79 μM。另外，3，4，和6显示了强的抑制带IC ₅₀ 7.67，6.03，和10.52微米，分别的值，对LPS诱导的NO生成。