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A New Benzophenone and Bioactive Constituents of Hypericum nokoense
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2021-07-14 , DOI: 10.1007/s10600-021-03441-8
Fu-Sen Wu , Ching-Ju Hung , Chien-Liang Lin , Hsueh-Yang Huang , Yueh-Hsiung Kuo , Tsung-Hsien Chang , Chun-Lin Chen , Ping-Jyun Sung , Ming-Jen Cheng , Chu-Wen Kuo , Jih-Jung Chen

A new benzophenone derivative, hyperinokone (1), has been isolated from the aerial part of Hypericum nokoense, together with six known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (4), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (5), and eleocharin A (6) exhibited cytotoxicities, with IC50 values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds 4 and 6 exhibited cytotoxicities, with IC50 values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition, 3, 4, and 6 showed potent inhibition with IC50 values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation.



中文翻译:

金丝桃的新二苯酮和生物活性成分

已从金丝桃的地上部分分离出一种新的二苯甲酮衍生物金丝桃酮 ( 1 ) ,以及六种已知化合物。通过光谱和质谱分析确定了新化合物1的结构。在分离株中,异茉莉花红素 ( 4 ) 、5,4'-二羟基-3'-甲氧基-(6:7)-2,2-二甲基吡喃黄酮 ( 5 ) 和马齿苋素 A ( 6 ) 表现出细胞毒性,IC 50值为针对 DLD-1 细胞系分别为 4.16、6.28 和 5.98 μM。化合物46表现出细胞毒性,IC 50针对 IMR-32 细胞系的值分别为 5.24 和 4.79 μM。另外,34,和6显示了强的抑制带IC 50 7.67,6.03,和10.52微米,分别的值,对LPS诱导的NO生成。

更新日期:2021-07-14
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