Objective: 

The aim was to assess the influence of corneal biomechanics on intraocular pressure (IOP) measurements made with the Icare200 (IC200) rebound tonometer and the Perkins handheld applanation tonometer in patients with primary congenital glaucoma (PCG).

Materials and Methods: 

A total of 40 PCG patients and 40 healthy controls, age, and sex-matched, were recruited. IOP was measured with the Ocular Response Analyzer (IOPc, IOPg), IC200 and Perkins. The variables age, IOP, corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), best-corrected visual acuity, spherical equivalent, medications, and glaucoma surgeries were recorded for each subject. Univariate and multivariate analysis were used to detect effects of variables on IOP measurements.

Results: 

Mean CCT was 545.65±71.88 μm in PCG versus 558.78±27.58 μm in controls (P=0.284). CH and CRF were significantly lower in PCG group than in control group: mean CH 8.11±1.69 versus 11.15±1.63 mm Hg (P<0.001), and mean CRF 9.27±2.35 versus 10.71±1.75 mm Hg (P=0.002). Mean differences between IOP IC200-Perkins were 0.79±0.53 mm Hg in PCG versus 0.80±0.23 mm Hg in controls (P<0.001) and mean differences IC200-IOPc were −0.89±5.15 mm Hg in PCG (P<0.001) versus 1.60±3.03 mm Hg in controls (all P<0.009). Through multivariate analysis, CRF showed positive association and CH negative association with IOP measured with Perkins or IC200 in both subject groups. No association was detected for CCT, age, or sex.

Conclusion: 

CH and CRF were identified as the main factors interfering with IOP measurements made with both tonometers in patients with PCG and healthy controls.

中文翻译：

---

角膜生物力学特性对原发性先天性青光眼患者回弹眼压计 (Icare200) 和压平眼压计 (Perkins) 读数的影响

客观的： 

目的是评估角膜生物力学对原发性先天性青光眼 (PCG) 患者使用 Icare200 (IC200) 回弹眼压计和 Perkins 手持式压平眼压计测量的眼内压 (IOP) 的影响。

材料和方法： 

总共招募了 40 名 PCG 患者和 40 名健康对照，年龄和性别均匹配。IOP 使用眼反应分析仪（IOPc、IOPg）、IC200 和 Perkins 进行测量。记录每个受试者的变量年龄、眼压、角膜滞后（CH）、角膜阻力因子（CRF）、中央角膜厚度（CCT）、最佳矫正视力、球镜等效值、药物和青光眼手术。使用单变量和多变量分析来检测变量对眼压测量的影响。

结果： 

PCG 中的平均 CCT 为 545.65±71.88 μm，而对照组为 558.78±27.58 μm（P =0.284）。PCG组的CH和CRF均显着低于对照组：平均CH为8.11±1.69 vs 11.15±1.63 mm Hg（P <0.001），平均CRF为9.27± 2.35 vs 10.71±1.75 mm Hg（P = 0.002）。PCG 中 IOP IC200-Perkins 之间的平均差异为 0.79±0.53 mm Hg，对照为 0.80±0.23 mm Hg（P <0.001），PCG 中 IC200-IOPc 的平均差异为 -0.89±5.15 mm Hg（P <0.001）与 1.60对照中 ±3.03 mm Hg（所有P <0.009）。通过多变量分析，在两个受试者组中，CRF 与用 Perkins 或 IC200 测量的 IOP 呈正相关，而 CH 呈负相关。未检测到 CCT、年龄或性别之间的关联。

结论： 

CH 和 CRF 被确定为干扰 PCG 患者和健康对照者使用眼压计进行 IOP 测量的主要因素。