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Corneal Endothelial Changes in Patients With Primary Congenital Glaucoma
Journal of Glaucoma ( IF 2.0 ) Pub Date : 2022-02-01 , DOI: 10.1097/ijg.0000000000001909
Nevbahar Tamçelik 1 , Bilge Batu Oto 1 , Burak Mergen 2 , Oğuzhan Kiliçarslan 1 , Busenur Gönen 1 , Ceyhun Arici 1
Affiliation  

Précis: 

Specular microscopic parameters were found to be decreased in patients with primary congenital glaucoma (PCG). Patients with PCG and Haab striae had lower endothelial cell density (ECD) and central corneal thickness (CCT) than those without Haab striae did. The type of surgery (viscogoniotomy, viscotrabeculotomy, or combined viscotrabeculotomy and trabeculectomy) did not affect specular microscopic parameters.

Purpose: 

The purpose of this study was to compare specular microscopic parameters such as corneal ECD, coefficient of variation (CV), hexagonal cell percentage (HEX), and CCT between patients with PCG and healthy controls; to determine the predictive ability of Haab striae for endothelial cell changes PCG by comparing patients with and without Haab striae; and to investigate if the type of surgery used to treat glaucoma (viscogoniotomy, viscotrabeculotomy, or combined viscotrabeculotomy and trabeculectomy) affects specular microscopic parameters.

Methods: 

A cross-sectional specular microscopic analysis of patients with PCG and healthy controls was performed. One hundred eyes of 62 patients with PCG with and without Haab striae and 101 eyes of 101 healthy controls were enrolled in this study. Specular microscopic parameters, including ECD, HEX, CV, and CCT, of all subjects were evaluated.

Results: 

Patients with PCG showed significantly lower ECD and CCT than healthy controls did. Those with Haab striae had lower ECD and CCT but no differences in age, HEX, and CV compared with those without Haab striae. ECD, CV, HEX, or CCT did not significantly differ among patients treated with the 3 different types of surgery.

Conclusions: 

Prolonged exposure to elevated intraocular pressure during prenatal and/or early postnatal life results in structural changes in immature infant corneas. Specular microscopic parameters differed significantly between healthy controls and patients with PCG. The type of surgery had no effect on these parameters. Among patients with PCG, those with Haab striae had isolated corneal endothelial cell loss without morphologic changes within the endothelium.



中文翻译:

原发性先天性青光眼患者角膜内皮的变化

概要: 

发现原发性先天性青光眼(PCG)患者的镜面显微镜参数下降。与没有 Haab纹的患者相比,有 PCG 和Haab 纹的患者的内皮细胞密度 (ECD) 和中央角膜厚度 (CCT) 较低。手术类型(粘性前角切开术、粘性小梁切开术或粘性小梁切开术和小梁切除术联合)不影响镜面显微镜参数。

目的: 

本研究的目的是比较 PCG 患者和健康对照者之间的镜面显微镜参数,如角膜 ECD、变异系数 (CV)、六角形细胞百分比 (HEX) 和 CCT;通过比较有和没有Haab 纹的患者,确定Haab 纹对内皮细胞变化 PCG的预测能力;并研究用于治疗青光眼的手术类型(粘性前角切开术、粘性小梁切开术或粘性小梁切开术和小梁切除术联合)是否影响镜面显微镜参数。

方法: 

对 PCG 患者和健康对照患者进行横断面镜面显微镜分析。本研究纳入了62 名伴有或不伴有Haab 纹的 PCG 患者的 100 只眼睛和 101 名健康对照的 101 只眼睛。对所有受试者的镜面显微镜参数(包括 ECD、HEX、CV 和 CCT)进行了评估。

结果: 

PCG 患者的 ECD 和 CCT 显着低于健康对照。与没有哈布纹的人相比,有哈布纹的的ECD 和 CCT 较低,但年龄、HEX 和 CV 没有差异。ECD、CV、HEX 或 CCT 在接受 3 种不同类型手术治疗的患者中没有显着差异。

结论: 

产前和/或产后早期长期暴露于升高的眼压会导致未成熟的婴儿角膜的结构变化。健康对照者和 PCG 患者之间的镜面显微镜参数存在显着差异。手术类型对这些参数没有影响。在患有 PCG 的患者中,患有Haab 纹的患者有孤立的角膜内皮细胞损失,但内皮内没有形态学变化。

更新日期:2022-02-01
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