We investigated the relationship between glucose variability and frailty. Forty-eight type 2 diabetic patients aged ≥ 65 years were enrolled. The FRAIL scale was used for frailty assessment, and participants were classified into 'healthy & pre-frail' (n = 24) and 'frail' (n = 24) groups. A continuous glucose monitoring (CGM) system was used for a mean of 6.9 days and standardized CGM metrics were analyzed: mean glucose, glucose management indicator (GMI), coefficient of variation, and time in range, time above range (TAR), and time below range. The demographics did not differ between groups. However, among the CGM metrics, mean glucose, GMI, and TAR in the postprandial periods were higher in the frail group (all P < 0.05). After multivariate adjustments, the post-lunch TAR (OR = 1.12, P = 0.019) affected the prevalence of frailty. Higher glucose variability with marked daytime postprandial hyperglycemia is significantly associated with frailty in older patients with diabetes.

中文翻译：

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老年糖尿病患者的日间血糖变化和虚弱：一项使用连续血糖监测的试点研究。

我们研究了葡萄糖变异性和虚弱之间的关系。48 名年龄≥ 65 岁的 2 型糖尿病患者入组。FRAIL 量表用于评估虚弱，参与者被分为“健康和虚弱前”（n = 24）和“虚弱”（n = 24）组。连续血糖监测 (CGM) 系统平均使用 6.9 天，并分析标准化的 CGM 指标：平均血糖、血糖管理指标 (GMI)、变异系数和范围内时间、超出范围时间 (TAR) 和时间低于范围。各组之间的人口统计学没有差异。然而，在 CGM 指标中，体弱组餐后的平均血糖、GMI 和 TAR 较高（均P < 0.05）。多变量调整后，午餐后 TAR (OR = 1.12,= 0.019) 影响虚弱的患病率。较高的葡萄糖变异性以及显着的日间餐后高血糖与老年糖尿病患者的虚弱显着相关。