Stem cell therapy has been used to treat several types of diseases, and it is expected that its therapeutic uses shall increase as novel lines of evidence begin to appear. Furthermore, stem cells have the potential to make new tissues and organs. Thus, some scientists propose that organ transplantation will significantly rely on stem cell technology and organogenesis in the future. Stem cells and its robust potential to differentiate into specific types of cells and regenerate tissues and body organs, have been investigated by numerous clinician scientists and researchers for their therapeutic effects. Degenerative diseases in different organs have been the main target of stem cell therapy. Neurodegenerative diseases such as Alzheimer's, musculoskeletal diseases such as osteoarthritis, congenital cardiovascular diseases, and blood cell diseases such as leukemia are among the health conditions that have benefited from stem cell therapy advancements. One of the most challenging parts of the process of incorporating stem cells into clinical practice is controlling their division and differentiation potentials. Sometimes, their potential for uncontrolled growth will make these cells tumorigenic. Another caveat in this process is the ability to control the differentiation process. While stem cells can easily differentiate into a wide variety of cells, a paracrine effect controlled activity, being in an appropriate medium will cause abnormal differentiation leading to treatment failure. In this review, we aim to provide an overview of the therapeutic effects of stem cells in diseases of various organ systems. In order to advance this new treatment to its full potential, researchers should focus on establishing methods to control the differentiation process, while policymakers should take an active role in providing adequate facilities and equipment for these projects. Large population clinical trials are a necessary tool that will help build trust in this method. Moreover, improving social awareness about the advantages and adverse effects of stem cell therapy is required to develop a rational demand in the society, and consequently, healthcare systems should consider established stem cell-based therapeutic methods in their treatment algorithms.

中文翻译：

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干细胞在不同身体系统中的治疗效果，一种尚未获得信任的新方法：综合综述。

干细胞疗法已被用于治疗多种疾病，预计随着新证据的出现，其治疗用途将会增加。此外，干细胞具有制造新组织和器官的潜力。因此，一些科学家提出器官移植将在未来显着依赖干细胞技术和器官发生。干细胞及其强大的分化成特定类型细胞和再生组织和身体器官的潜力，已被众多临床科学家和研究人员研究其治疗效果。不同器官的退行性疾病一直是干细胞治疗的主要目标。阿尔茨海默氏症等神经退行性疾病、骨关节炎等肌肉骨骼疾病、先天性心血管疾病、和白血病等血细胞疾病是受益于干细胞疗法进步的健康状况之一。将干细胞纳入临床实践过程中最具挑战性的部分之一是控制它们的分裂和分化潜能。有时，它们不受控制的生长潜力会使这些细胞致瘤。此过程中的另一个警告是控制分化过程的能力。虽然干细胞可以很容易地分化成多种细胞，但旁分泌效应控制活性，在适当的培养基中会导致异常分化导致治疗失败。在这篇综述中，我们旨在概述干细胞在各种器官系统疾病中的治疗作用。为了充分发挥这种新疗法的潜力，研究人员应侧重于建立控制差异化过程的方法，而政策制定者应发挥积极作用，为这些项目提供充足的设施和设备。大规模的临床试验是一种必要的工具，有助于建立对这种方法的信任。此外，需要提高社会对干细胞治疗优势和副作用的认识，以发展社会的理性需求，因此，医疗保健系统应在其治疗算法中考虑已建立的基于干细胞的治疗方法。大规模的临床试验是一种必要的工具，有助于建立对这种方法的信任。此外，需要提高社会对干细胞治疗优势和副作用的认识，以发展社会的理性需求，因此，医疗保健系统应在其治疗算法中考虑已建立的基于干细胞的治疗方法。大规模的临床试验是一种必要的工具，有助于建立对这种方法的信任。此外，需要提高社会对干细胞治疗优势和副作用的认识，以发展社会的理性需求，因此，医疗保健系统应在其治疗算法中考虑已建立的基于干细胞的治疗方法。