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Aboard the ISS: intersubunit signaling revealed in the p97 ATPase
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2021-07-14 , DOI: 10.1038/s41594-021-00622-5
Edward C Twomey 1, 2
Affiliation  

A new cryo-EM study reveals how ATP hydrolysis in the p97 ATPase is coordinated to unfold the protein’s substrates and provides new foundations for the design of small molecule therapeutics targeting p97 in cancer, neurodegeneration and viral infection.

中文翻译:

在国际空间站上:p97 ATPase 中揭示的亚基间信号

一项新的冷冻电镜研究揭示了 p97 ATP 酶中的 ATP 水解是如何协调展开蛋白质底物的,并为设计针对癌症、神经变性和病毒感染中的 p97 的小分子疗法提供了新的基础。
更新日期:2021-07-14
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