Since the start of 2020, the world has been upended by the pandemic caused by the severe acute respiratory coronavirus type 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). It has not only led to a tragic loss of life and terrible economic costs but has also been met with an unprecedented response of the scientific and medical communities. In an effort to better understand this viral infection, scientists around the world generated the largest surge in research in documented history for any topic (Lever & Altman, 2021). A part of this work has included the need to better understand the impact of the virus on human proteins—the key machinery of the cell—and human physiology. In their recent study, Geyer and colleagues (Geyer et al, 2021) analyzed a total of 720 proteomes from longitudinal serum samples of 31 hospitalized COVID-19 patients and control individuals with COVID-19-like symptoms but not infected with SARS-CoV-2, providing a comprehensive characterization of the plasma proteome changes along the time course of infection.

中文翻译：

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血浆蛋白质组学揭示的个体 COVID-19 疾病轨迹

自 2020 年初以来，由严重急性呼吸道冠状病毒 2 (SARS-CoV-2) 引起的大流行颠覆了世界，该病毒是 2019 年冠状病毒病 (COVID-19) 的病原体。它不仅导致了悲惨的生命损失和可怕的经济损失，而且还引起了科学界和医学界前所未有的反应。为了更好地了解这种病毒感染，世界各地的科学家对任何主题进行了有史以来最大的研究热潮（Lever & Altman，2021 年）。这项工作的一部分包括需要更好地了解病毒对人类蛋白质（细胞的关键机制）和人类生理学的影响。在他们最近的研究中，Geyer 及其同事（Geyer等人, 2021) 分析了 31 名住院 COVID-19 患者和具有 COVID-19 样症状但未感染 SARS-CoV-2 的对照个体的纵向血清样本中的总共 720 个蛋白质组，提供了血浆蛋白质组变化的综合表征。感染的时间过程。