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Efficient Construction of (±)-epi-Costunolide through a Chromium(II)-Mediated Nozaki–Hiyama–Kishi Reaction
Synlett ( IF 1.7 ) Pub Date : 2021-07-13 , DOI: 10.1055/s-0040-1720348
Lihong Hu 1 , Yinan Zhang 1 , Weichen Dai 1, 2 , Jie Zheng 1 , Xinyu Yan 1 , Wei Tang 3
Affiliation  

(±)-epi-Costunolide has been synthesized through a seven-step procedure starting from (E,E)-farnesol. The key step includes an intramolecular allylation of an aldehyde through a chromium(II)-mediated Nozaki–Hiyama–Kishi reaction, in which more than one equivalent of CrCl2 has been recognized as the most effective reagent to promote the conversion. An anti-inflammatory screen showed that epi-costunolide is a moderate inhibitor of B lymphocyte proliferation.



中文翻译:

通过铬 (II) 介导的 Nozaki-Hiyama-Kishi 反应有效构建 (±)-epi-Costunolide

(±) -外延-Costunolide已通过从(起始七步方法合成ëê)法呢醇。关键步骤包括通过铬 (II) 介导的 Nozaki-Hiyama-Kishi 反应使醛分子内烯丙基化,其中超过一当量的 CrCl 2被认为是促进转化的最有效试剂。抗炎筛选显示木香内酯是 B 淋巴细胞增殖的中度抑制剂。

更新日期:2021-07-14
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