Pd-Catalyzed 2,3-Allenylation of Oxindoles with 2,3-Allenylic Carbonates,Chinese Journal of Chemistry

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Pd-Catalyzed 2,3-Allenylation of Oxindoles with 2,3-Allenylic Carbonates
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2021-07-14 , DOI: 10.1002/cjoc.202100402
Jie Lin ₁ , Minqiang Jia ₁ , Shengming Ma _{1,

2}

Affiliation

Allenes and oxindoles are two classes of very important compounds for medicinal chemistry and organic chemistry. Thus, it is of high interest to combine an allene and an oxindole into one molecule. Herein, the first example of palladium-catalyzed exclusive 2,3-allenylation reaction of oxindoles with 2,3-allenylic carbonates has been successfully developed. A rationale for the selectivity of 2,3-allenylation over the expected 1,3-alkadienylation has been proposed.

中文翻译：

Pd 催化的氧化吲哚与 2,3-烯丙基碳酸酯的 2,3-烯丙基化

Allenes 和oxindoles 是两类非常重要的化合物，用于药物化学和有机化学。因此，将丙二烯和羟吲哚结合成一个分子是非常有意义的。在此，成功开发了钯催化的羟基吲哚与 2,3-烯丙基碳酸酯的专属 2,3-烯丙基化反应的第一个实例。已经提出了 2,3- 烯基化比预期的 1,3- 链二烯基化的选择性的基本原理。

更新日期：2021-07-14

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