A 13-year-old healthy girl presented with dizziness and palpitations, found to have a left atrial mass. An 8-cm tumor was removed en bloc. Pathology confirmed grade 3 leiomyosarcoma with multifocal positive margins. She received adjuvant ifosfamide and doxorubicin, followed by concurrent proton radiotherapy and ifosfamide. Radiotherapy included 66 Gy (RBE) in 33 fractions to the operative bed. Prospectively graded toxicities included Grade 2 esophagitis and Grade 1 anorexia, dermatitis, and fatigue. She completed six cycles of ifosfamide. Two years post operation, she had no evidence of disease, intermittent palpitations with normal cardiac function, and no other cardiopulmonary or esophageal symptoms.

中文翻译：

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儿童高级别心脏平滑肌肉瘤的辅助放化疗：病例报告及文献复习

一名 13 岁健康女孩出现头晕和心悸，被发现有左心房肿块。一个 8 厘米的肿瘤被整块切除。病理学证实具有多灶阳性边缘的 3 级平滑肌肉瘤。她接受了异环磷酰胺和多柔比星的辅助治疗，然后是同时进行的质子放疗和异环磷酰胺。放射治疗包括 66 Gy (RBE) 分 33 次到手术床。前瞻性分级毒性包括 2 级食管炎和 1 级厌食、皮炎和疲劳。她完成了六个周期的异环磷酰胺。术后两年，她没有任何疾病迹象，间歇性心悸，心功能正常，也没有其他心肺或食道症状。