This study explored the clinical effectiveness of antibiotic-loaded bone cement on primary treatment of diabetic foot infection. This is a randomized controlled study, including thirty-six patients with diabetic foot ulcer complicated by osteomyelitis who had undergone treatment between May 2018 and December 2019. Patients were randomly divided into control group (group A) and study group (group B). Patients in the intervention group received antibiotic-loaded bone cement repair as primary treatment, while patients in the control group received conventional vacuum sealing draining treatment. Clinical endpoints were assessed and compared between the two groups, including wound healing time, wound bacterial conversion, NRS pain score, number of wound dressing changes, and average hospitalization time. All patients were followed up for a period of 12 months after discharge. Results show that compared with the control group, patients in the study group had significant difference in the number of patients for baseline pathogens eradication, short NRS pain score, hospital length of stay and cost, wound surface reduction, healing time, low rate of complications, and infection recurrence. Based on the findings, we conclude that antibiotic-loaded bone cement can be used for treatment of wound in patient with diabetic foot infection. It can help to control wound infections, shorten hospital length of stay, reduce medical cost, and relieve both doctors’ and patients’ burden. The application of antibiotic-loaded bone cement is suitable for diabetic wound with soft tissue infection or osteomyelitis.

中文翻译：

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抗生素骨水泥促进软组织造粒在治疗神经性糖尿病足溃疡合并骨髓炎中的应用及临床疗效：一项随机对照试验

本研究探讨了抗生素骨水泥在糖尿病足感染初级治疗中的临床疗效。本研究为随机对照研究，纳入2018年5月至2019年12月接受治疗的36例糖尿病足溃疡并发骨髓炎患者，随机分为对照组（A组）和研究组（B组）。干预组患者接受抗生素骨水泥修复作为主要治疗，而对照组患者接受常规负压封闭引流治疗。评估和比较两组临床终点，包括伤口愈合时间、伤口细菌转化、NRS疼痛评分、伤口敷料更换次数和平均住院时间。所有患者出院后随访12个月。结果显示，与对照组相比，研究组患者在根除基线病原菌数、NRS疼痛评分短、住院时间和费用、创面缩小、愈合时间、并发症发生率低等方面有显着差异。和感染复发。根据研究结果，我们得出结论，负载抗生素的骨水泥可用于治疗糖尿病足感染患者的伤口。有助于控制伤口感染，缩短住院时间，降低医疗费用，减轻医患负担。抗生素骨水泥的应用适用于软组织感染或骨髓炎的糖尿病创面。结果显示，与对照组相比，研究组患者在根除基线病原菌数、NRS疼痛评分短、住院时间和费用、创面缩小、愈合时间、并发症发生率低等方面有显着差异。和感染复发。根据研究结果，我们得出结论，负载抗生素的骨水泥可用于治疗糖尿病足感染患者的伤口。有助于控制伤口感染，缩短住院时间，降低医疗费用，减轻医患负担。抗生素骨水泥的应用适用于软组织感染或骨髓炎的糖尿病创面。结果显示，与对照组相比，研究组患者在根除基线病原菌数、NRS疼痛评分短、住院时间和费用、创面缩小、愈合时间、并发症发生率低等方面有显着差异。和感染复发。根据研究结果，我们得出结论，负载抗生素的骨水泥可用于治疗糖尿病足感染患者的伤口。有助于控制伤口感染，缩短住院时间，降低医疗费用，减轻医患负担。抗生素骨水泥的应用适用于软组织感染或骨髓炎的糖尿病创面。研究组患者在根除基线病原菌的患者数量、短期 NRS 疼痛评分、住院时间和费用、创面缩小、愈合时间、并发症发生率低、感染复发率等方面存在显着差异。根据研究结果，我们得出结论，负载抗生素的骨水泥可用于治疗糖尿病足感染患者的伤口。有助于控制伤口感染，缩短住院时间，降低医疗费用，减轻医患负担。抗生素骨水泥的应用适用于软组织感染或骨髓炎的糖尿病创面。研究组患者在根除基线病原菌的患者数量、短期 NRS 疼痛评分、住院时间和费用、创面缩小、愈合时间、并发症发生率低、感染复发率等方面存在显着差异。根据研究结果，我们得出结论，负载抗生素的骨水泥可用于治疗糖尿病足感染患者的伤口。有助于控制伤口感染，缩短住院时间，降低医疗费用，减轻医患负担。抗生素骨水泥的应用适用于软组织感染或骨髓炎的糖尿病创面。我们得出结论，负载抗生素的骨水泥可用于治疗糖尿病足感染患者的伤口。有助于控制伤口感染，缩短住院时间，降低医疗费用，减轻医患负担。抗生素骨水泥的应用适用于软组织感染或骨髓炎的糖尿病创面。我们得出结论，负载抗生素的骨水泥可用于治疗糖尿病足感染患者的伤口。有助于控制伤口感染，缩短住院时间，降低医疗费用，减轻医患负担。抗生素骨水泥的应用适用于软组织感染或骨髓炎的糖尿病创面。