COVID-19 has led to a great deal of general suffering and an increased prevalence of psychiatric illness worldwide. Within the area of psychosis-risk syndromes, a highly heterogeneous clinical population, the picture is quite nuanced as the social restrictions resulting from the pandemic have reduced stress for some and increased it for others. Further, a number of pandemic-related societal and cultural changes have obfuscated the diagnostic and treatment landscape in this area as well. In this opinion article, we describe several prototypical cases, representative of presentations seen in our clinical high-risk (CHR) research programs. The cases highlight considerable clinical variability and, in addition, speak to the current complexities faced by diagnosticians and treatment providers. In addition to discussing these issues, this piece introduces potential solutions highlighting the promise of incorporating data-driven strategies to identify more homogenous CHR subtypes and employ precision medicine.

中文翻译：

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COVID-19 大流行给临床精神病高危人群带来了诊断和治疗计划的复杂性


COVID-19 给全世界带来了巨大的痛苦，精神疾病的患病率也随之增加。在精神病风险综合征领域，临床人群具有高度异质性，情况非常微妙，因为大流行造成的社会限制减少了一些人的压力，却增加了另一些人的压力。此外，一些与大流行相关的社会和文化变化也混淆了该领域的诊断和治疗前景。在这篇观点文章中，我们描述了几个典型案例，代表了我们临床高风险 (CHR) 研究项目中的表现。这些病例凸显了相当大的临床变异性，此外还说明了诊断医生和治疗提供者当前面临的复杂性。除了讨论这些问题之外，本文还介绍了潜在的解决方案，强调了结合数据驱动策略来识别更同质的 CHR 亚型并采用精准医疗的前景。