Accumulating evidence has demonstrated that cancer stem cells (CSCs) play an essential role in tumor progression and reoccurrence and drug resistance. Multiple signaling pathways have been revealed to be critically participated in CSC development and maintenance. Emerging evidence indicates that numerous chemopreventive compounds, also known as nutraceuticals, could eliminate CSCs in part via regulating several signaling pathways. Therefore, in this review, we will describe the some natural chemopreventive agents that target CSCs in a variety of human malignancies, including soy isoflavone, curcumin, resveratrol, tea polyphenols, sulforaphane, quercetin, indole-3-carbinol, 3,3'-diindolylmethane, withaferin A, apigenin, etc. Moreover, we discuss that eliminating CSCs by nutraceuticals might be a promising strategy for treating human cancer via overcoming drug resistance and reducing tumor reoccurrence.

越来越多的证据表明，癌症干细胞 (CSC) 在肿瘤进展和复发以及耐药性中发挥着重要作用。已发现多种信号通路在 CSC 的发展和维持中发挥着重要作用。新出现的证据表明，许多化学预防化合物，也称为营养品，可以通过调节几种信号通路部分消除 CSC。因此，在这篇综述中，我们将描述一些针对多种人类恶性肿瘤中 CSCs 的天然化学预防剂，包括大豆异黄酮、姜黄素、白藜芦醇、茶多酚、萝卜硫素、槲皮素、吲哚-3-甲醇、3,3'-二吲哚基甲烷、withaferin A、芹菜素等。此外，