Abstract

A simple and efficient TEMPO-mediated system for aerobic oxidative synthesis of 2-aryl benzoxazoles from readily available benzoxazoles and primary benzylic and hetero benzylic amines is presented in one pot. The reaction proceeds through the ring-opening of benzoxazoles and is followed by oxidative condensation with benzylamines. These metal-free, straightforward reactions worked well with a wide range of substrates, yielding moderate to good yields under mild conditions using air as an external green oxidant.

中文翻译：

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通过苯并恶唑与苄胺开环，TEMPO 介导的 2-芳基苯并恶唑有氧氧化合成

摘要

一种简单有效的 TEMPO 介导系统，用于从容易获得的苯并恶唑和伯苄基和杂苄基胺有氧氧化合成 2-芳基苯并恶唑。该反应通过苯并恶唑的开环进行，然后与苄胺氧化缩合。这些不含金属的、直接的反应适用于各种底物，在使用空气作为外部绿色氧化剂的温和条件下产生中等至良好的产率。