Abstract

Increasing efforts have been focused on development of novel therapeutic approaches based on a carrier mixed with polymeric microparticles (MPs) for promoting bioactive factors delivery. Polymers as poly (lactide-co-glycolide) are the most widely used due to their tunable physico-chemical properties and biomimetic character. Here, PLGA-MPs of different surface charges were dispersed in hyaluronic acid and their impact on the viability of four cell lines was studied. Our data reveal that the most evident effect is the influence of the cell line proliferation-rate on PLGA-MPs stability and aggregation, highlighting the crucial role of the biological context in affecting microparticles clustering and toxicity.

摘要

越来越多的努力集中在开发基于与聚合物微粒 (MP) 混合的载体的新型治疗方法，以促进生物活性因子的递送。聚合物作为聚（丙交酯-共-乙交酯）由于其可调节的物理化学性质和仿生特性而得到最广泛的应用。在这里，不同表面电荷的 PLGA-MP 分散在透明质酸中，并研究了它们对四种细胞系活力的影响。我们的数据显示，最明显的影响是细胞系增殖率对 PLGA-MPs 稳定性和聚集的影响，突出了生物环境在影响微粒聚集和毒性方面的关键作用。