Aim: The aim of the study was to assess the antihyperglycemic activity of Brassica oleracea.

Background: Collard green or Brassica oleracea var. viridis which belongs to Brassicaceae family is ranked at 10th place of “powerhouse” vegetables, and it is commonly used traditionally for the treatment of diabetes in Morocco.

Objective: This current investigation aimed to assess the antihyperglycemic capacity of the aqueous extract of Collard green leaves.

Methods: The effect of a single (6 hours) and repeated (seven days of treatment) oral administration of Collard green aqueous extract (CGAE) at a dose of 60 mg/kg on glucose and lipid profile was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of liver was carried out according to the Hematoxylin-Eosin method. Furthermore, a preliminary phytochemical screening, and the quantification of phenolic, flavonoid and tannins contents as well as the antioxidant activity using DPPH assay were carried out.

Results: The results demonstrated that Collard green A.E. (CGAE) exhibited a significant antihyperglycemic effect and positive improvement liver histology in diabetic rats. After a single oral administration of CGAE, blood glucose levels were lowered from 15±2 mM to 4.9±1 mM (p<0.0001) at the sixth hour in diabetic rats but no change was observed in normal rats. Repeated CGAE administration was able to reduce blood glucose levels from 15±2 mM to normal values (5±1 mM at the seventh day, p<0.0001) while the extract had no effect in normal rats. In addition, we revealed that CGAE is rich in several phytochemical compounds and exerts an important antioxidant activity.

Conclusion: In conclusion, this study demonstrates that Collard green possesses a beneficial effect against diabetes and can be used in the program diet of diabetic patients.

目的：该研究的目的是评估甘蓝的抗高血糖活性。

背景：羽衣甘蓝或芸苔变种。属于十字花科的绿萝在“强者”蔬菜中排名第十，摩洛哥传统上常用来治疗糖尿病。

目的：本研究旨在评估羽衣甘蓝叶水提取物的抗高血糖能力。

方法：检查单次（6 小时）和重复（治疗 7 天）口服 60 毫克/千克剂量的羽衣甘蓝水提取物 (CGAE) 对正常和链脲佐菌素诱导的葡萄糖和脂质谱的影响。糖尿病大鼠。此外，根据苏木精-伊红法对肝脏进行组织病理学检查。此外，还进行了初步植物化学筛选，并使用 DPPH 测定法对酚类、黄酮类和单宁含量以及抗氧化活性进行了量化。

结果：结果表明， Collard green AE (CGAE) 在糖尿病大鼠中表现出显着的降血糖作用和积极的改善肝脏组织学。单次口服 CGAE 后，糖尿病大鼠的血糖水平在第 6 小时从 15±2 mM 降至 4.9±1 mM (p<0.0001)，但在正常大鼠中未观察到变化。重复给予 CGAE 能够将血糖水平从 15±2 mM 降低到正常值（第 7 天时为 5±1 mM，p<0.0001），而提取物对正常大鼠没有影响。此外，我们发现 CGAE 富含多种植物化学化合物，并发挥重要的抗氧化活性。

结论：总而言之，本研究表明羽衣甘蓝对糖尿病具有有益作用，可用于糖尿病患者的计划饮食。