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A high-efficient method for the amidation of carboxylic acids promoted by triphenylphosphine oxide and oxalyl chloride
Heteroatom Chemistry ( IF 1.1 ) Pub Date : 2017-01-19 , DOI: 10.1002/hc.21364
Lixue Jiang 1 , Jing Yu 1 , Fanfan Niu 1 , Derundong Zhang 1 , Xiaoling Sun 1
Affiliation  

A effective amidation reaction of carboxylic acids with various amines promoted by triphenylphosphine oxide and oxalyl chloride under mild and neutral conditions has been developed. The feature of this procedure was the using and recycling of triphenylphosphine oxide at room temperature in 0.5 h. Furthermore a plausible mechanism also be deduced with the help of 31P NMR spectroscopy.

中文翻译:

三苯基氧化膦和草酰氯促进羧酸酰胺化的高效方法

已经开发了在温和和中性条件下由三苯基氧化膦和草酰氯促进的羧酸与各种胺的有效酰胺化反应。该程序的特点是在室温下0.5小时内使用和回收三苯基氧化膦。此外,还可以借助 31P NMR 光谱推断出一个合理的机制。
更新日期:2017-01-19
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