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How much epigenetics and quantitative trait loci (QTL) mapping tell us about parasitism maintenance and resistance/susceptibility to hosts
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ( IF 4.2 ) Pub Date : 2021-07-13 , DOI: 10.1016/j.bbadis.2021.166214
Aline Marrara Prado 1 , Bárbara Maria Cerqueira Maia 1 , Marlene Tiduko Ueta 2 , Fernanda Janku Cabral 2
Affiliation  

Interactions between the environment, parasites, vectors, and/or intermediate hosts are complex and involve several factors that define the success or failure of an infection. Among these interactions that can affect infections by a parasite, it is possible to highlight the genetic and epigenetic mechanisms in hosts and parasites. The interaction between genetics, epigenetics, infection, and the host's internal and external environment is decisive and dictates the outcome of a parasitic infection and the resistance, susceptibility, and transmission of this parasite. Epigenetic changes become important mediators in the regulation of gene expression, allowing the evasion of the parasite to immune host barriers, its transmission to new hosts, and the end of its development cycle. Epigenetics is a new frontier in the understanding of the interaction mechanisms between parasite and host that, along with information from the gene regions associated with complex phenotypic variations, the Quantitative Trait Loci, brings new possibilities to investigate more modern and efficient approaches to the treatment, control, and eradication of parasitic diseases. In this brief review, a general overview of the use of epigenetic information and mapping of Quantitative Trait Loci was summarized, both in genes of parasites and hosts, for understanding the mechanisms of resistance and/or susceptibility in parasitic relationships; also, the main search platforms were quantitatively compared, aiming to facilitate access data produced over a period of twenty years.



中文翻译:

多少表观遗传学和数量性状基因座 (QTL) 作图告诉我们寄生维持和对宿主的抗性/易感性

环境、寄生虫、载体和/或中间宿主之间的相互作用是复杂的,并且涉及定义感染成功或失败的几个因素。在这些可能影响寄生虫感染的相互作用中,有可能突出宿主和寄生虫的遗传和表观遗传机制。遗传学、表观遗传学、感染和宿主内部和外部环境之间的相互作用是决定性的,并决定了寄生虫感染的结果以及这种寄生虫的抵抗力、易感性和传播。表观遗传变化成为调节基因表达的重要介质,使寄生虫能够逃避免疫宿主的屏障,将其传播给新宿主,并结束其发育周期。表观遗传学是理解寄生虫和宿主之间相互作用机制的新前沿,连同来自与复杂表型变异相关的基因区域的信息,数量性状位点,为研究更现代和有效的治疗方法带来了新的可能性,控制和消灭寄生虫病。在这篇简短的综述中,概述了在寄生虫和宿主基因中使用表观遗传信息和定量性状基因座作图的一般概述,以了解寄生虫关系中的抗性和/或易感性机制;此外,还对主要搜索平台进行了定量比较,旨在促进访问二十年间产生的数据。连同来自与复杂表型变异相关的基因区域的信息,定量性状位点为研究更现代、更有效的寄生虫病治疗、控制和根除方法带来了新的可能性。在这篇简短的综述中,概述了在寄生虫和宿主基因中使用表观遗传信息和定量性状基因座作图的一般概述,以了解寄生虫关系中的抗性和/或易感性机制;此外,还对主要搜索平台进行了定量比较,旨在促进访问二十年间产生的数据。连同来自与复杂表型变异相关的基因区域的信息,定量性状位点为研究更现代、更有效的寄生虫病治疗、控制和根除方法带来了新的可能性。在这篇简短的综述中,概述了在寄生虫和宿主基因中使用表观遗传信息和定量性状基因座作图的一般概述,以了解寄生虫关系中的抗性和/或易感性机制;此外,还对主要搜索平台进行了定量比较,旨在促进访问二十年间产生的数据。和消灭寄生虫病。在这篇简短的综述中,概述了在寄生虫和宿主基因中使用表观遗传信息和定量性状基因座作图的一般概述,以了解寄生虫关系中的抗性和/或易感性机制;此外,还对主要搜索平台进行了定量比较,旨在促进访问二十年间产生的数据。和消灭寄生虫病。在这篇简短的综述中,概述了在寄生虫和宿主基因中使用表观遗传信息和定量性状基因座作图的一般概述,以了解寄生虫关系中的抗性和/或易感性机制;此外,还对主要搜索平台进行了定量比较,旨在促进访问二十年间产生的数据。

更新日期:2021-07-27
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