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Chemical and biological profile of Psidium bahianum landrum & funch (Myrtaceae)
Brazilian Journal of Botany ( IF 1.4 ) Pub Date : 2021-07-13 , DOI: 10.1007/s40415-021-00727-7
Thais dos Santos Rocha 1 , Edson de Jesus Marques 1 , Camila Machado do Nascimento 1 , Lourdes Cardoso de Souza Neta 1 , Vera Lúcia Costa Vale 1 , Marcos da Costa Silva 2 , Rafael Ribeiro Mota Souza 3
Affiliation  

Plant species of the genus Psidium L. (family Myrtaceae) metabolize a wide range of secondary metabolites. These are reflected in the variety of biological activities expressed by extracts and isolated components from these plants, which have aroused the interest of several researchers. The chemical and pharmacological potential of Psidium bahianum Landrumn & Funch, a species endemic to eastern Bahia State, Brazil, has, until now, not been reported. This work investigates the chemical composition and antimicrobial, antioxidant and cytotoxic potential of extracts obtained from P. bahianum in solvents of different polarities by antimicrobial inhibition, free radical capture, Arthemia salina Leach viability, and hemolytic activity essays, respectively. Phytochemical assays revealed the presence of alkaloids, triterpenoids, steroids, saponins, anthraquinones, phenols and flavonoids. The extracts showed antimicrobial activity for the Gram-positive bacteria Staphylococcus aureus Rosenbach and Micrococcus luteus Schroeter and for the Gram-negative bacteria Pseudomonas aeruginosa Schroeter and Salmonella choleraesuis Smith, in addition to antifungal activity against Candida albicans Robin Berkhout. Ethyl acetate and ethanol extracts also showed high free radical reducing capacities the DPPH (≥ 80%). The samples did not demonstrate toxic potential by means of hemolytic assay, but the leaf extracts in ethyl acetate and ethanol, which presented moderate toxicity for A. salina with CL50 values of 489.80 and 323.60 µg mL−1, respectively. These findings show for the first time the chemical and biological profiles of P. bahianum extracts, contributing to the safety of their traditional use, as well as, in the long term, to the preparation of herbal medicines.



中文翻译:

Psidium bahianum landrum & funch(桃金娘科)的化学和生物特征

Psidium L.属植物物种(桃金娘科)代谢多种次生代谢物。这些反映在这些植物的提取物和分离成分所表达的各种生物活性上,这引起了一些研究人员的兴趣。Psidium bahianum Landrumn & Funch是巴西巴伊亚州东部特有的物种,其化学和药理潜力直到现在还没有报道。这项工作研究了化学组合物和由获得的提取物的抗微生物剂,抗氧化剂和细胞毒潜力P. bahianum通过抗微生物抑制在不同极性的溶剂中,自由基捕捉,Arthemia藻分别为浸出活力和溶血活性论文。植物化学分析显示存在生物碱、三萜类化合物、类固醇、皂苷、蒽醌、酚类和黄酮类化合物。除了对白色念珠菌的抗真菌活性外,提取物还对革兰氏阳性菌罗森巴赫葡萄球菌藤黄微球菌以及革兰氏阴性菌铜绿假单胞菌猪霍乱沙门氏菌具有抗菌活性罗宾·伯克豪特。乙酸乙酯和乙醇提取物也显示出高自由基还原能力 DPPH (≥ 80%)。通过溶血试验,样品没有显示出潜在的毒性,但是乙酸乙酯和乙醇中的叶提取物对盐生藻具有中等毒性,CL 50值分别为489.80 和323.60 µg mL -1。这些发现首次显示了巴哈伊豆提取物的化学和生物特征,有助于其传统用途的安全性,以及从长远来看,有助于草药的制备。

更新日期:2021-07-13
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