G protein-coupled estrogen receptor in the rostral ventromedial medulla contributes to the chronification of postoperative pain,CNS Neuroscience & Therapeutics

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G protein-coupled estrogen receptor in the rostral ventromedial medulla contributes to the chronification of postoperative pain
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-07-13 , DOI: 10.1111/cns.13704
Jia-Jia Xu _{1,

2} , Po Gao ₂ , Ying Wu ₁ , Su-Qing Yin ₂ , Ling Zhu ₂ , Sai-Hong Xu ₂ , Dan Tang ₂ , Chi-Wai Cheung ₃ , Ying-Fu Jiao ₂ , Wei-Feng Yu ₂ , Yuan-Hai Li ₁ , Li-Qun Yang ₂

Affiliation

Chronification of postoperative pain is a common clinical phenomenon following surgical operation, and it perplexes a great number of patients. Estrogen and its membrane receptor (G protein-coupled estrogen receptor, GPER) play a crucial role in pain regulation. Here, we explored the role of GPER in the rostral ventromedial medulla (RVM) during chronic postoperative pain and search for the possible mechanism.

中文翻译：

延髓头端腹内侧的 G 蛋白偶联雌激素受体有助于术后疼痛的慢性化

术后疼痛的慢性化是外科手术后常见的临床现象，困扰着广大患者。雌激素及其膜受体（G蛋白偶联雌激素受体，GPER）在疼痛调节中起着至关重要的作用。在这里，我们探讨了 GPER 在慢性术后疼痛期间在延髓头端腹内侧 (RVM) 中的作用，并寻找可能的机制。

更新日期：2021-07-13

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