The suppressors of cytokine signalling (SOCS) family plays negative roles in regulating cytokine signalling pathways that related to immunity, growth and development. In the present study, eight SOCS genes were characterized from golden pompano (Trachinotus ovatus), a marine teleost with great economic values. The eight SOCSs of golden pompano possess conserved motifs that found in other fish SOCSs. The obtained SOCSs shared high sequence identities with their counterparts in other fish species, confirmed by phylogenetic tree analysis. Quantitative real-time PCR revealed that the eight SOCS genes were ubiquitously expressed in all the selected tissues of normal golden pompano. After lipopolysaccharide (LPS), polyI:C and Vibrioalginilyticus challenged in vivo, the SOCS genes of golden pompano exhibited distinct expression patterns in spleen and head kidney (HK). Our results indicated that SOCSs involve in the immune response to viral or bacterial infection in golden pompano. To the best of our knowledge, this is the first report on SOCSs in golden pompano.

中文翻译：

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金鲳 (Trachinotus ovatus) 细胞因子信号抑制因子的分子特征和表达分析

细胞因子信号传导抑制因子 (SOCS) 家族在调节与免疫、生长和发育相关的细胞因子信号通路中起负面作用。在本研究中，八个 SOCS 基因从具有巨大经济价值的海洋硬骨鱼金鲳（Trachinotus ovatus）中表征。Golden pompano 的八个 SOCS 具有在其他鱼类 SOCS 中发现的保守图案。通过系统发育树分析证实，获得的 SOCS 与其他鱼类中的对应物具有高序列同一性。定量实时 PCR 显示 8 个 SOCS 基因在所有选定的正常金鲳鱼组织中普遍表达。在脂多糖 (LPS)、polyI:C 和Vibrioalginilyticus体内挑战之后，金凤梨的 SOCS 基因在脾脏和头肾 (HK) 中表现出不同的表达模式。我们的研究结果表明，SOCSs 参与了金孔雀鱼对病毒或细菌感染的免疫反应。据我们所知，这是关于金色庞帕诺 SOCS 的第一份报告。