Fenugreek (Trigonella foenum-graecum) seed is a popular kitchen spice and medicinal herb with wide applications in Indian folklore. Earlier studies have shown that the hydro-ethanolic extracts of fenugreek are efficient in the management of a number of hormone related disorders in women, including post and peri-menopausal discomforts, sexual dysfunctions, lactation and even in amenorrhea. However, systematic informations on their safety and influence on hormonal balance are limited. Forty-eight healthy menstruating women aged 20 to 48 were randomized either to FHE (n = 24) or placebo (n = 24) and supplemented with 250 mg × 2/day for 42 days. FHE did not produce any side effects or adverse events. It offered significant (P < 0.05) beneficial effects to sexual problems (41.6%) and irritability (40%) among the participants who had higher sexual dysfunctions scores (> 1) when monitored by the validated Menopausal Rating Scale (MRS) scale. Further, hormone analysis indicated an enhancement in estradiol (P = 0.040), free testosterone (P = 0.025), and total testosterone (P = 0.012) in FHE group in comparison to placebo. There were no significant changes in progesterone (P = 0.174) and FSH (P = 0.879) upon FHE supplementation. The hematological and biochemical safety parameters were also at par with the safety of the extract. Thus, the supplementation of FHE may be considered as a natural alternative for sexual issues in women. CTRI/2018/09/015614 dated 05/09/2018.

中文翻译：

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胡芦巴新提取物对健康年轻女性的安全性和影响：一项随机、双盲、安慰剂对照研究

胡芦巴 (Trigonella foenum-graecum) 种子是一种流行的厨房香料和药草，在印度民间传说中有着广泛的应用。早期的研究表明，胡芦巴的水乙醇提取物可有效治疗女性的许多激素相关疾病，包括绝经后和围绝经期不适、性功能障碍、哺乳期甚至闭经。然而，关于它们的安全性和对荷尔蒙平衡的影响的系统信息是有限的。48 名 20 至 48 岁的健康经期女性随机接受 FHE（n = 24）或安慰剂（n = 24），并补充 250 mg × 2/天，持续 42 天。FHE 没有产生任何副作用或不良事件。它为性问题提供了显着（P < 0.05）的有益效果（41. 在经过验证的更年期评定量表 (MRS) 量表监测时，性功能障碍评分较高 (> 1) 的参与者中有 6%) 和易怒 (40%)。此外，激素分析表明，与安慰剂相比，FHE 组的雌二醇 (P = 0.040)、游离睾酮 (P = 0.025) 和总睾酮 (P = 0.012) 有所增强。补充 FHE 后，孕酮 (P = 0.174) 和 FSH (P = 0.879) 没有显着变化。血液学和生化安全参数也与提取物的安全性相当。因此，补充 FHE 可能被认为是解决女性性问题的自然选择。CTRI/2018/09/015614 日期为 05/09/2018。激素分析表明，与安慰剂相比，FHE 组的雌二醇 (P = 0.040)、游离睾酮 (P = 0.025) 和总睾酮 (P = 0.012) 有所增强。补充 FHE 后，孕酮 (P = 0.174) 和 FSH (P = 0.879) 没有显着变化。血液学和生化安全参数也与提取物的安全性相当。因此，补充 FHE 可能被认为是解决女性性问题的自然选择。CTRI/2018/09/015614 日期为 05/09/2018。激素分析表明，与安慰剂相比，FHE 组的雌二醇 (P = 0.040)、游离睾酮 (P = 0.025) 和总睾酮 (P = 0.012) 有所增强。补充 FHE 后，孕酮 (P = 0.174) 和 FSH (P = 0.879) 没有显着变化。血液学和生化安全参数也与提取物的安全性相当。因此，补充 FHE 可能被认为是解决女性性问题的自然选择。CTRI/2018/09/015614 日期为 05/09/2018。补充 FHE 可能被认为是解决女性性问题的自然选择。CTRI/2018/09/015614 日期为 05/09/2018。补充 FHE 可能被认为是解决女性性问题的自然选择。CTRI/2018/09/015614 日期为 05/09/2018。