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Anti-inflammatory and analgesic properties of Moroccan medicinal plants: Phytochemistry, in vitro and in vivo investigations, mechanism insights, clinical evidences and perspectives
Journal of Pharmaceutical Analysis ( IF 6.1 ) Pub Date : 2021-07-13 , DOI: 10.1016/j.jpha.2021.07.004
Abdelhakim Bouyahya 1 , Fatima-Ezzahrae Guaouguaou 2 , Nasreddine El Omari 3 , Naoual El Menyiy 4 , Abdelaali Balahbib 5 , Mohamed El-Shazly 6, 7 , Youssef Bakri 1
Affiliation  

Moroccan medicinal plants exhibit several pharmacological properties such as antimicrobial, anticancer, antidiabetic, analgesic, and anti-inflammatory effects, which are related to the presence of numerous bioactive compounds, including phenolic acids, flavonoids, and terpenoids. In the present review, we systematically evaluate previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal plants. The in vitro investigations revealed that Moroccan medicinal plants inhibit several enzymes related to inflammatory processes, whereas in vivo studies noted significant anti-inflammatory and analgesic effects as demonstrated using different experimental models. Various bioactive compounds exhibiting in vitro and in vivo anti-inflammatory and analgesic effects, with diverse mechanisms of action, have been identified. Some plants and their bioactive compounds reveal specific secondary metabolites that possess important anti-inflammatory effects in clinical investigations. Our review proposes the potential applications of Moroccan medicinal plants as sources of anti-inflammatory and analgesic agents.



中文翻译:

摩洛哥药用植物的抗炎和镇痛特性:植物化学、体外和体内研究、机制见解、临床证据和观点

摩洛哥药用植物表现出多种药理特性,如抗菌、抗癌、抗糖尿病、镇痛和抗炎作用,这与许多生物活性化合物的存在有关,包括酚酸、类黄酮和萜类化合物。在本综述中,我们系统地评估了先前发表的关于摩洛哥药用植物抗炎和镇痛作用的报告。体外研究表明,摩洛哥药用植物抑制了几种与炎症过程相关的酶,而体内研究表明,使用不同的实验模型显示出显着的抗炎和镇痛作用。已鉴定出具有多种作用机制的多种生物活性化合物,它们在体外和体内具有抗炎和镇痛作用。一些植物及其生物活性化合物揭示了在临床研究中具有重要抗炎作用的特定次级代谢物。我们的审查提出了摩洛哥药用植物作为抗炎和镇痛剂来源的潜在应用。

更新日期:2021-07-13
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