Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2021-07-13 , DOI: 10.1016/j.jneuroim.2021.577661 Luca Baldelli 1 , Giulia Amore 2 , Angelica Montini 1 , Ivan Panzera 1 , Simone Rossi 1 , Pietro Cortelli 2 , Maria Guarino 3 , Rita Rinaldi 3 , Roberto D'Angelo 3
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We describe the first case of hyperacute reversible encephalopathy following COVID-19 vaccination. A patient presented with acute onset encephalopathy, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset. The clinical manifestation was related with systemic and CSF cytokine hyperproduction, responsive to steroid therapy. Although the occurrence of encephalopathy after vaccination may be just a casual temporal association, we speculate that the cytokine-storm could be the result of an excessive innate immune response against the vaccine, in a predisposed patient susceptible to autoimmunity.
中文翻译：
COVID-19 疫苗接种后与细胞因子风暴相关的超急性可逆性脑病
我们描述了首例 COVID-19 疫苗接种后超急性可逆性脑病病例。一名患者出现急性发作性脑病，主要特征是激越和意识模糊，对高剂量类固醇治疗反应迅速，并在发病后 3 天内完全缓解。临床表现与全身和 CSF 细胞因子过度产生有关，对类固醇治疗有反应。尽管疫苗接种后脑病的发生可能只是偶然的时间关联，但我们推测细胞因子风暴可能是易患自身免疫的易感患者对疫苗产生过度先天免疫反应的结果。
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