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Reactive oxygen species-responsive degradable poly(amino acid)s for biomedical use
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2021-07-13 , DOI: 10.1002/app.51386 Xiaoxia Fan 1 , Sudi Zhu 1 , Lin Yan 1 , Hui Zhu 1
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2021-07-13 , DOI: 10.1002/app.51386 Xiaoxia Fan 1 , Sudi Zhu 1 , Lin Yan 1 , Hui Zhu 1
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A series of reactive oxygen species-responsive degradable poly(amino acid)s (PAAs) was synthesized via in situ melting polycondensation. The PAAs were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry, thermogravimetric analysis, and mechanical property analysis. The degradation and biocompatibility of the PAAs were also studied to evaluate their applicability as biomedical materials. The results show that the PAAs possessed semicrystalline amide structures, and the PAA melting temperature decreased gradually with increasing methionine loading. The incorporation of methionine decreased the thermal stability of the matrix, leading to decreases in both the initial and maximum degradation temperatures. The mechanical properties of the PAAs deteriorated as the content of methionine increased. The content of methionine had an obvious effect on PAA degradation, and the PAAs were responsive to the reactive oxygen-rich environment, suggesting that the incorporation of methionine is effective at improving the degradation of PAAs. The PAAs showed great in vitro and in vivo biocompatibilities. Based on the results, these polymers show promise as high-performance materials for biomedical applications.
中文翻译：
用于生物医学用途的活性氧响应性可降解聚（氨基酸）
通过原位熔融缩聚反应合成了一系列活性氧响应的可降解聚（氨基酸）（PAA）。通过 X 射线衍射、傅里叶变换红外光谱、扫描电子显微镜、差示扫描量热法、热重分析和机械性能分析对 PAA 进行了表征。还研究了 PAA 的降解和生物相容性，以评估它们作为生物医学材料的适用性。结果表明，PAA具有半结晶的酰胺结构，随着蛋氨酸负载量的增加，PAA的熔化温度逐渐降低。甲硫氨酸的加入降低了基质的热稳定性，导致初始和最大降解温度降低。PAA 的机械性能随着蛋氨酸含量的增加而恶化。蛋氨酸的含量对PAA的降解有明显的影响，PAA对富活性氧环境有响应，表明蛋氨酸的掺入可以有效地改善PAA的降解。PAA 显示出很好的体外和体内生物相容性。根据结果，这些聚合物显示出作为生物医学应用高性能材料的前景。
更新日期：2021-09-09
中文翻译：
用于生物医学用途的活性氧响应性可降解聚（氨基酸）
通过原位熔融缩聚反应合成了一系列活性氧响应的可降解聚（氨基酸）（PAA）。通过 X 射线衍射、傅里叶变换红外光谱、扫描电子显微镜、差示扫描量热法、热重分析和机械性能分析对 PAA 进行了表征。还研究了 PAA 的降解和生物相容性，以评估它们作为生物医学材料的适用性。结果表明，PAA具有半结晶的酰胺结构，随着蛋氨酸负载量的增加，PAA的熔化温度逐渐降低。甲硫氨酸的加入降低了基质的热稳定性，导致初始和最大降解温度降低。PAA 的机械性能随着蛋氨酸含量的增加而恶化。蛋氨酸的含量对PAA的降解有明显的影响，PAA对富活性氧环境有响应，表明蛋氨酸的掺入可以有效地改善PAA的降解。PAA 显示出很好的体外和体内生物相容性。根据结果，这些聚合物显示出作为生物医学应用高性能材料的前景。
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