The increased use of immune-checkpoint inhibitors to treat various types of cancer has increased the incidence of immune-related adverse events (irAEs). Hepatic irAEs are frequent and can lead to serious conditions. Among the various types of hepatic irAEs reported to date, bile duct injury has been shown refractory to steroid treatment. This study describes 2 patients with hepatic irAEs manifesting as intrahepatic bile duct injury. Immunostaining with antibodies to both CD8 and cytokeratin-7 was useful for the diagnosis, and both patients were refractory to steroid treatment. Prompt diagnosis and active immunosuppressive therapies are required in such cases.
Case Rep Gastroenterol 2021;15:645–651

中文翻译：

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肝内胆管损伤作为免疫检查点抑制剂治疗后肝脏免疫相关的不良事件

越来越多地使用免疫检查点抑制剂来治疗各种类型的癌症，增加了免疫相关不良事件 (irAE) 的发生率。肝脏 irAE 很常见，可导致严重的疾病。在迄今为止报道的各种类型的肝脏 irAE 中，胆管损伤已被证明对类固醇治疗无效。本研究描述了 2 名表现为肝内胆管损伤的肝脏 irAE 患者。CD8 和 cytokeratin-7 抗体的免疫染色有助于诊断，并且两名患者均对类固醇治疗无效。在这种情况下需要及时诊断和积极的免疫抑制治疗。
Case Rep Gastroenterol 2021；15:645–651