ABSTRACT

Objectives

To examine early adult deaths (EAD) – people aged 55–74 due to brain disease deaths (BDD) compared to all other causes (AOC) in the 21st century in 21 major Western countries (MWC).

Method

EAD are below MWCc average life expectancy. All mortality drawn from the latest WHO data. The three global BDD categories consist of mental and behaviour disorder, nervous diseases and Alzheimer and other dementias. Mortality rates per million are analysed for people 55–74 years and total age-standardised death rates (ASDR). BDD rates between 2000–2015 compared against AOC of deaths for EAD and ASDR. Confidence Intervals determine any significant difference AOC and BDD over the period 2000–15, plus an examination of EAD in six separate global mortality categories.

Results

EAD: The separate BDD categories for EAD significantly positively correlated, validating their combination as BDD. Every country’s AOC 55–74 rates fell substantially, but fourteen country’s BDD rose substantially (>20%) and all MWC countries BDD rose significantly more than AOC. ASDR: All nations total AOC fell substantially, whereas seventeen BDD rates rose substantially and every country’s BDD significantly increased compared to AOC deaths. Six other EAD mortalities, circulatory, cancer, respiratory, compared to BDD produced Odds Ratios ranging from 1:1.54 to 1:2.36 such were the marked differences over the period.

Discussion

Positive news is that AOC are down across all investigated countries in the 21st century. However, the extent of the EAD rises in just 16 years indicates that these BDD conditions are starting earlier suggesting multiple interactive environmental factors impacting upon brain related diseases.

中文翻译：

---

21 世纪早期成人（55-74 岁）脑部疾病死亡人数与西方主要国家所有其他原因死亡人数的比较——揭露隐藏的流行病

摘要

目标

检验 21 世纪 21 个主要西方国家 (MWC) 中 55-74 岁因脑病死亡 (BDD) 与所有其他原因 (AOC) 相比的成人早期死亡 (EAD)。

方法

EAD 低于 MWCc 的平均预期寿命。所有死亡率均来自最新的世卫组织数据。三个全球 BDD 类别包括精神和行为障碍、神经疾病以及阿尔茨海默病和其他痴呆症。分析了 55-74 岁人群的每百万死亡率和总年龄标准化死亡率 (ASDR)。与 EAD 和 ASDR 的死亡 AOC 相比，2000-2015 年的 BDD 率。置信区间确定了 2000-15 年期间 AOC 和 BDD 的任何显着差异，以及在六个不同的全球死亡率类别中对 EAD 的检查。

结果

EAD：EAD 的单独 BDD 类别显着正相关，验证它们的组合为 BDD。每个国家的 AOC 55-74 比率都大幅下降，但有 14 个国家的 BDD 大幅上升（>20%），所有 MWC 国家 BDD 的上升幅度都明显超过 AOC。ASDR：所有国家的总 AOC 均大幅下降，而 17 个 BDD 率大幅上升，与 AOC 死亡人数相比，每个国家的 BDD 均显着增加。与 BDD 相比，其他六种 EAD 死亡率（循环系统、癌症、呼吸系统）产生的赔率比从 1:1.54 到 1:2.36 不等，这是该时期的显着差异。

讨论

积极的消息是，21 世纪所有被调查国家的 AOC 都下降了。然而，EAD 在短短 16 年内上升的程度表明，这些 BDD 条件开始得更早，这表明多种交互环境因素会影响大脑相关疾病。