LATE-NC is a diagnostic term developed by a large, multidisciplinary, international team of experts, after months of discussion and a NIH-funded 2 day in-person meeting in late 2018. This group was tasked with generating suitable terminology for common TDP-43 proteinopathy in aging. When diagnosing an unusual case of TDP-43 proteinopathy at autopsy, a diagnostic approach is recommended that is analogous to unusual tauopathy or α-synucleinopathy cases: render a descriptive neuropathologic diagnosis, rather than label such cases as LATE-NC.

中文翻译：

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如何处理不寻常的 TDP-43 蛋白病病例？

LATE-NC 是一个由大型、多学科、国际专家团队开发的诊断术语，经过数月的讨论和 2018 年底 NIH 资助的为期 2 天的面对面会议。该小组的任务是为常见的 TDP- 生成合适的术语43 衰老中的蛋白质病。在尸检时诊断不寻常的 TDP-43 蛋白病病例时，建议采用类似于不寻常的 tauopathy 或 α-突触核蛋白病病例的诊断方法：进行描述性神经病理学诊断，而不是将此类病例标记为 LATE-NC。