The therapeutic value of mesenchymal stem cells (MSCs) for the treatment of infectious diseases and the repair of disease-induced tissue damage has been explored extensively. MSCs inhibit inflammation, reduce pathogen load and tissue damage encountered during infectious diseases through the secretion of antimicrobial factors for pathogen clearance and they phagocytose certain bacteria themselves. MSCs dampen tissue damage during infection by downregulating the levels of pro-inflammatory cytokines, and inhibiting the excessive recruitment of neutrophils and proliferation of T cells at the site of injury. MSCs aid in the regeneration of damaged tissue by differentiating into the damaged cell types or by releasing paracrine factors that direct tissue regeneration, differentiation, and wound healing. In this review, we discuss in detail the various mechanisms by which MSCs help combat pathogens, tissue damage associated with infectious diseases, and challenges in utilizing MSCs for therapy.

中文翻译：

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回顾间充质干细胞治疗传染病的潜力。

间充质干细胞 (MSCs) 在治疗传染病和修复疾病引起的组织损伤方面的治疗价值已被广泛探索。间充质干细胞通过分泌用于清除病原体的抗菌因子来抑制炎症、减少病原体载量和减少传染病期间遇到的组织损伤，并且它们自身吞噬某些细菌。间充质干细胞通过下调促炎细胞因子的水平，抑制损伤部位中性粒细胞的过度募集和 T 细胞的增殖，从而抑制感染过程中的组织损伤。间充质干细胞通过分化为受损细胞类型或通过释放指导组织再生、分化和伤口愈合的旁分泌因子来帮助受损组织的再生。在这次审查中，