Inflammatory periodontal disease known as periodontitis is one of the most common conditions that affect human teeth and often leads to tooth loss. Due to the complexity of the periodontium, which is composed of several tissues, its regeneration and subsequent return to a homeostatic state is challenging with the therapies currently available. Cellular therapy is increasingly becoming an alternative in regenerative medicine/dentistry, especially therapies using mesenchymal stem cells, as they can be isolated from a myriad of tissues. Periodontal ligament stem cells (PDLSCs) are probably the most adequate to be used as a cell source with the aim of regenerating the periodontium. Biological insights have also highlighted PDLSCs as promising immunomodulator agents. In this review, we explore the state of knowledge regarding the properties of PDLSCs, as well as their therapeutic potential, describing current and future clinical applications based on tissue engineering techniques.

中文翻译：

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牙周膜干细胞的治疗潜力。

称为牙周炎的炎症性牙周病是影响人类牙齿的最常见疾病之一，通常会导致牙齿脱落。由于牙周组织的复杂性，牙周组织由多种组织组成，其再生和随后恢复到稳态状态对于目前可用的疗法具有挑战性。细胞疗法正日益成为再生医学/牙科的替代方案，尤其是使用间充质干细胞的疗法，因为它们可以从无数组织中分离出来。牙周膜干细胞 (PDLSC) 可能是最适合用作细胞来源以再生牙周膜的细胞来源。生物学见解也强调了 PDLSCs 作为有前途的免疫调节剂。在这篇综述中，我们探索了关于 PDLSCs 特性的知识状态，