Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study,Brain and Behavior

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Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study
Brain and Behavior ( IF 2.6 ) Pub Date : 2021-07-13 , DOI: 10.1002/brb3.2134
Peter N Hadar ₁ , Lohith G Kini ₂ , Ravi Prakash Reddy Nanga ₃ , Russell T Shinohara ₄ , Stephanie H Chen ₁ , Preya Shah ₂ , Laura E M Wisse ₅ , Mark A Elliott ₃ , Hari Hariharan ₃ , Ravinder Reddy ₃ , John A Detre ₃ , Joel M Stein ₆ , Sandhitsu Das ₅ , Kathryn A Davis ₁

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Drug-resistant epilepsy patients show worse outcomes after resection when standard neuroimaging is nonlesional, which occurs in one-third of patients. In prior work, we employed 2-D glutamate imaging, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to lateralize seizure onset in nonlesional temporal lobe epilepsy (TLE) based on increased ipsilateral GluCEST signal in the total hippocampus and hippocampal head. We present a significant advancement to single-slice GluCEST imaging, allowing for three-dimensional analysis of brain glutamate networks.

中文翻译：

使用 7T MRI 的体积谷氨酸成像 (GluCEST) 可以使非病变性颞叶癫痫偏侧化：一项初步研究

当标准的神经影像学检查无病变时，耐药性癫痫患者在切除后表现出更差的结果，这种情况发生在三分之一的患者中。在之前的工作中，我们采用二维谷氨酸成像、谷氨酸化学交换饱和转移 (GluCEST)，根据总海马和海马头部中同侧 GluCEST 信号的增加，将非病变性颞叶癫痫 (TLE) 的癫痫发作侧化。我们展示了单切片 GluCEST 成像的重大进步，允许对大脑谷氨酸网络进行三维分析。

更新日期：2021-09-03

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