Bixin is an apocarotenoid derived from Bixa orellana L. well known as a food colorant along with its numerous industrial and therapeutic applications. With the current surge in usage of natural products, bixin has contributed immensely to the world carotenoid market and showcases a spike in its requirement globally. To bridge the gap between bixin availability and utility, owed to its bioactivity and demand as a colouring agent in industries the sustainable production of bixin is critical. Therefore, to meet up this challenge effective use of multidisciplinary strategies is a promising choice to enhance bixin quantity and quality. Here we report, an optimal blend of approaches directed towards manipulation of bixin biosynthesis pathway with an insight into the impact of regulatory mechanisms and environmental dynamics, engineering carotenoid degradation in plants other than annatto, usage of tissue culture techniques supported with diverse elicitations, molecular breeding, application of in silico predictive tools, screening of microbial bio-factories as alternatives, preservation of bixin bioavailability, and promotion of eco-friendly extraction techniques to play a collaborative role in promoting sustainable bixin production.

Bixin 是一种源自Bixa orellana的类胡萝卜素L. 作为一种食品着色剂以及其众多的工业和治疗应用而广为人知。随着目前天然产品使用量的激增，碧心为世界类胡萝卜素市场做出了巨大贡献，并展示了其全球需求量的激增。为了弥合 bixin 可用性和实用性之间的差距，由于 bixin 的生物活性和作为工业着色剂的需求，bixin 的可持续生产至关重要。因此，为了应对这一挑战，有效利用多学科策略是提高碧信数量和质量的一个有希望的选择。在这里，我们报告了一种最佳混合方法，旨在操纵 bixin 生物合成途径，并深入了解调节机制和环境动力学的影响，工程除胭脂树以外的植物中的类胡萝卜素降解，计算机预测工具、筛选微生物生物工厂作为替代品、保持碧玺生物利用度、推广环保提取技术，在促进可持续碧玺生产方面发挥协同作用。