Abstract

Extraintestinal disease manifestations of inflammatory bowel disease (IBD), such as arthritis and uveitis, have been well described in the medical literature. However, there has been growing evidence suggesting an association between IBD and both coronary artery disease (CAD) and acute myocardial infarctions (AMI). In this critical review, the pathogenesis of proatherogenic inflammatory markers (CD40-CD40L, IL-6, and TNF-α) are summarised along with clinical evidence that supports the association of these makers with CAD. Moreover, clinical data are examined that suggest an increased risk of AMI and CAD in IBD patients along with recent analyses of in-hospital and post-MI outcomes of AMI in IBD patients. This comprehensive review summarises and expands upon our understanding of the growing association between both CAD and AMI in IBD patients that potentially identifies IBD as a risk factor for developing CAD.

摘要

炎症性肠病 (IBD) 的肠外疾病表现，如关节炎和葡萄膜炎，已在医学文献中得到充分描述。然而，越来越多的证据表明 IBD 与冠状动脉疾病 (CAD) 和急性心肌梗死 (AMI) 之间存在关联。在这篇重要的综述中，总结了促动脉粥样硬化炎症标志物（CD40-CD40L、IL-6 和 TNF-α）的发病机制以及支持这些标志物与 CAD 相关的临床证据。此外，检查表明 IBD 患者 AMI 和 CAD 风险增加的临床数据以及最近对 IBD 患者 AMI 的院内和 MI 后结果的分析。