Advances in prostatic stroma studies over the past few decades have demonstrated that the stroma not only supports and nourishes the gland's secretory epithelium but also participates in key aspects of morphogenesis, in the prostate's hormonal metabolism, and in the functionality of the secretory epithelium. Furthermore, the stroma is implicated in the onset and progression of prostate cancer through the formation of the so-called reactive stroma, which corresponds to a tumorigenesis-permissive microenvironment. Prostatic stromal cells are interconnected and exchange paracrine signals among themselves in a gland that is highly sensitive to endocrine hormones. There is a growing body of evidence that telocytes, recently detected interstitial cells that are also present in the prostate, are involved in stromal organization, so that their processes form a network of interconnections with both the epithelium and the other stromal cells. The present review provides an update on the different types of prostate stromal cells, their interrelationships and implications for prostate development, physiology and pathological conditions.

中文翻译：

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基质细胞在前列腺发育、生理和病理状况中的相互作用

过去几十年前列腺基质研究的进展表明，基质不仅支持和滋养腺体的分泌上皮，而且还参与形态发生、前列腺激素代谢和分泌上皮功能的关键方面。此外，基质通过所谓的反应性基质的形成与前列腺癌的发病和进展有关，这对应于允许肿瘤发生的微环境。前列腺基质细胞相互连接并在对内分泌激素高度敏感的腺体中相互交换旁分泌信号。越来越多的证据表明，最近检测到的间质细胞也存在于前列腺中，它参与了基质组织，以便它们的过程与上皮细胞和其他基质细胞形成互连网络。本综述提供了关于不同类型的前列腺基质细胞、它们的相互关系以及对前列腺发育、生理学和病理状况的影响的最新情况。