Progress in Cardiovascular Diseases ( IF 5.6 ) Pub Date : 2021-07-13 , DOI: 10.1016/j.pcad.2021.07.005 Jesús Beltrán-García 1 , Rebeca Osca-Verdegal 2 , Elena Nácher-Sendra 3 , Alejandro Cardona-Monzonís 4 , Fabian Sanchis-Gomar 5 , Nieves Carbonell 6 , Federico V Pallardó 1 , Carl J Lavie 7 , José Luis García-Giménez 8
The mechanisms occurring during sepsis that produce an increased risk of cardiovascular (CV) disease (CVD) are poorly understood. Even less information exists regarding CV dysfunction as a complication of sepsis, particularly for sepsis-induced cardiomyopathy. However, recent research has demonstrated that non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in genetic reprogramming, gene regulation, and inflammation during the development of CVD.
Here we describe experimental findings showing the importance of non-coding RNAs mediating relevant mechanisms underlying CV dysfunction after sepsis, so contributing to sepsis-induced cardiomyopathy. Importantly, non-coding RNAs are critical novel regulators of CVD risk factors. Thus, they are potential candidates to improve diagnostics and prognosis of sepsis-induced cardiomyopathy and other CVD events occurring after sepsis and set the basis to design novel therapeutic strategies.
中文翻译:
非编码 RNA 作为败血症中有害心血管作用的生物标志物的作用
脓毒症期间发生的导致心血管 (CV) 疾病 (CVD) 风险增加的机制知之甚少。关于 CV 功能障碍作为败血症并发症的信息更少,特别是对于败血症引起的心肌病。然而,最近的研究表明,非编码 RNA,包括 microRNA、长链非编码 RNA 和环状 RNA,在 CVD 发展过程中的基因重编程、基因调控和炎症中起着至关重要的作用。
在这里,我们描述了实验结果,表明非编码 RNA 介导脓毒症后 CV 功能障碍的相关机制的重要性,因此有助于脓毒症诱导的心肌病。重要的是,非编码 RNA 是 CVD 风险因素的关键新型调节剂。因此,它们是改善败血症诱发的心肌病和败血症后发生的其他 CVD 事件的诊断和预后的潜在候选者,并为设计新的治疗策略奠定了基础。