The mechanisms occurring during sepsis that produce an increased risk of cardiovascular (CV) disease (CVD) are poorly understood. Even less information exists regarding CV dysfunction as a complication of sepsis, particularly for sepsis-induced cardiomyopathy. However, recent research has demonstrated that non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in genetic reprogramming, gene regulation, and inflammation during the development of CVD.

Here we describe experimental findings showing the importance of non-coding RNAs mediating relevant mechanisms underlying CV dysfunction after sepsis, so contributing to sepsis-induced cardiomyopathy. Importantly, non-coding RNAs are critical novel regulators of CVD risk factors. Thus, they are potential candidates to improve diagnostics and prognosis of sepsis-induced cardiomyopathy and other CVD events occurring after sepsis and set the basis to design novel therapeutic strategies.

脓毒症期间发生的导致心血管 (CV) 疾病 (CVD) 风险增加的机制知之甚少。关于 CV 功能障碍作为败血症并发症的信息更少，特别是对于败血症引起的心肌病。然而，最近的研究表明，非编码 RNA，包括 microRNA、长链非编码 RNA 和环状 RNA，在 CVD 发展过程中的基因重编程、基因调控和炎症中起着至关重要的作用。

在这里，我们描述了实验结果，表明非编码 RNA 介导脓毒症后 CV 功能障碍的相关机制的重要性，因此有助于脓毒症诱导的心肌病。重要的是，非编码 RNA 是 CVD 风险因素的关键新型调节剂。因此，它们是改善败血症诱发的心肌病和败血症后发生的其他 CVD 事件的诊断和预后的潜在候选者，并为设计新的治疗策略奠定了基础。