Design, Synthesis and anticancer evaluation of 2-(5-(Benzo[d]thiazol-2-yl)-1H-imidazol-1-yl)-5-aryl-1H-benzo[d]imidazole derivatives,Chemical Data Collections

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Design, Synthesis and anticancer evaluation of 2-(5-(Benzo[d]thiazol-2-yl)-1H-imidazol-1-yl)-5-aryl-1H-benzo[d]imidazole derivatives
Chemical Data Collections Pub Date : 2021-07-13 , DOI: 10.1016/j.cdc.2021.100753
Perugu Edukondalu ₁ , Reddymasu Sireesha ₁ , Chandra Mohan Bandaru ₁ , Mandava Venkata Basaveswara Rao ₂ , Pruthu Kala ₁ , Rudraraju Ramesh Raju ₁

Affiliation

A library of 2-(5-(benzo[d]thiazol-2-yl)-1H-imidazol-1-yl)-5-aryl-1H-benzo[d] imidazole derivatives (7a–j) were designed, synthesized and tested for their anticancer activity towards four human cancer cell lines namely MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian). Among them, compounds 7b, 7c, 7g and 7i have shown more promising activity compared to the positive control - Etoposide. Of these, compound 7b displayed highest anticancer activity against breast and lung cancer cell lines (MCF-7 and A549) with IC₅₀ values of 0.018 ± 0.0039 µM and 0.011 ± 0.0019 µM.

中文翻译：

2-(5-(苯并[d]噻唑-2-基)-1H-咪唑-1-基)-5-芳基-1H-苯并[d]咪唑衍生物的设计、合成和抗癌评价

设计、合成了 2-(5-(benzo[d]thiazol-2-yl)-1H-imidazol-1-yl)-5-aryl-1H-benzo[d] 咪唑衍生物 ( 7a–j ) 库并测试了它们对四种人类癌细胞系的抗癌活性，即 MCF-7（乳腺）、A549（肺）、Colo-205（结肠）和 A2780（卵巢）。其中，与阳性对照物依托泊苷相比，化合物7b、7c、7g和7i显示出更有前景的活性。其中，化合物7b对乳腺癌和肺癌细胞系（MCF-7 和 A549）显示出最高的抗癌活性，IC ₅₀值为 0.018 ± 0.0039 µM 和 0.011 ± 0.0019 µM。

更新日期：2021-07-29

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