The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or APCs. These include roles in homotypic T cell–T cell (T–T) communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.

整合素 LFA-1 对于 T 细胞进入哺乳动物淋巴结和组织以及促进与抗原呈递细胞 (APC) 的相互作用至关重要。然而，越来越明显的是，LFA-1 除了支持 T 细胞、内皮和/或 APC 之间的粘附之外，还具有其他关键作用。这些包括在同型 T 细胞-T 细胞 (T-T) 通讯中的作用、诱导 Th1 效应细胞极化的细胞内补体活性以及支持持久的 T 细胞记忆。在这里，我们简要总结了 LFA-1 生物学的当前知识，讨论了 LFA-1 功能的新型细胞骨架调节因子，并回顾了 LFA-1 机械生物学的新方面，这些方面与其在免疫突触中的功能以及 LFA-1 引起的特定病理学相关。失调。