With the global epidemics of obesity and associated conditions, including type 2 diabetes, metabolic dysfunction-associated fatty liver disease, chronic kidney disease, hypertension, stroke, cardiovascular disease, osteoporosis, cancer, and cognitive changes, the prevalence of multimorbidity is rapidly increasing worldwide. In this Review, a panel of international experts from across the spectrum of metabolic diseases come together to identify the challenges and provide perspectives on building a framework for a virtual primary care-driven, patient-centred, multidisciplinary model to deliver holistic care for patients with metabolic dysfunction-associated fatty liver disease and associated metabolic diseases. We focus on clinical care and innovative trial design for metabolic dysfunction-associated fatty liver disease and associated metabolic diseases. This work represents a call to action to promote collaboration and partnerships between stakeholders for improving the lives of people with, or at risk of, metabolic dysfunction-associated fatty liver disease and associated metabolic diseases.

随着肥胖症和相关疾病的全球流行，包括 2 型糖尿病、代谢功能障碍相关的脂肪肝病、慢性肾病、高血压、中风、心血管疾病、骨质疏松症、癌症和认知改变，全球多发病率正在迅速增加. 在本次审查中，来自代谢疾病谱系的国际专家小组齐聚一堂，确定挑战并提供观点，以构建虚拟初级保健驱动、以患者为中心的多学科模型框架，为患有慢性疾病的患者提供整体护理代谢功能障碍相关的脂肪肝和相关代谢疾病。我们专注于代谢功能障碍相关脂肪肝和相关代谢疾病的临床护理和创新试验设计。这项工作代表了一项行动呼吁，以促进利益相关者之间的合作和伙伴关系，以改善患有代谢功能障碍相关脂肪肝和相关代谢疾病或有风险的人们的生活。